| Wednesday, 16 January, 2019 | |
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| All Day | Exhibit Setup |
| 10:00 – 19:00 | Registration Open |
| 10:00 – 18:00 | Poster Setup |
| 12:00 – 16:00 | TOXINS 101 Preconference Workshop Learn more |
| 18:00 – 19:30 | Opening Session Chair: Giampietro Schiavo (UK) |
| 18:00 – 18:30 | Opening Remarks and Lifetime Achievement Awards Ceremony Co-chairs: Giampietro Schiavo (UK) Mark Hallett (USA) |
| 18:30 – 19:00 | Presentation by Basic Science Lifetime Achievement Award Recipient Cesare Montecucco (Italy) |
| 19:00 – 19:30 | Presentation by Clinical Lifetime Achievement Award Recipient Joseph Jankovic (USA) |
| 19:30 – 22:00 | Welcome Reception |
| Thursday, 17 January, 2019 | |
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| 07:00 – 18:30 | Registration/Information |
| 07:00 – 08:30 | Exhibits & Breakfast |
| 08:30 – 12:00 | Plenary Session Pain and Sensory Mechanisms Chair: Mark Hallett (USA) |
| 08:30 – 08:40 | Opening Remarks and Introduction of Keynote Speaker |
| 08:40 – 09:30 | Keynote Presentation – Mechanisms of Pain Stephen McMahon (UK) |
| 09:30 – 10:00 | Emerging Clinical Uses for BoNT in Relation to Pain Nadine Attal (France) |
| 10:00 – 10:30 | Novel Analgesics Zdravko Lackovic (Croatia) |
| 10:30 – 11:00 | BREAK |
| 11:00 – 11:30 | Headache Cristina Tassorelli (Italy) |
| 11:30 – 12:00 | Central Effects in Sensory and Pain Networks Rami Burstein (USA) |
| 12:00 – 13:30 | Lunch |
| 12:00 – 14:30 | Exhibits |
| 12:00 – 14:30 | Poster Session |
| PARALLEL TRACKS | Basic Science Track | Clinical Track 1A | Clinical Workshop 1A | Clinical Workshop 2A | Clinical Workshop 3A | Clinical Workshop 4A | Clinical Workshop 5A | ||
|---|---|---|---|---|---|---|---|---|---|
| 14:30 – 16:00 | Emerging Toxins and Toxin Engineering Co-chairs: Eric Johnson (USA) Miia Lindström (Finland) |
Current and Emerging GI/GU Applications of BoNT Session Chair: Michael Chancellor (USA) |
Cadaver Laboratory – Prosection of the Head and Neck – A Mostly Aesthetic Perspective Session Chair: Steven G. Yoelin (USA) |
Newly-Diagnosed Cervical Dystonia Session Chair: Cynthia Comella (USA) |
Adult Spasticity Session Chair: Alberto Esquenazi (USA) |
Lower Cranial Dystonias and Drooling Session Chair: Andrew Blitzer (USA) |
Hands-on Ultrasound Guidance Hands-on Workshop Session Chair: Katherine Alter (USA) Learn more |
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| 14:30 – 15:00 | What Defines a Botulinum Neurotoxin–Toxin Diversity Eric Johnson (USA) |
Clinical Applications in the Male GU Tract: Benign Prostatic Hyperplasia, Chronic Pelvic Pain Syndrome, Cancer Emmanuel Chartier-Kastler (France) Potential Clinical Applications for BoNT in the GI Tract Frank Zerbib (France) The Role of BoNT in “Classic” Bladder Disorders: Clinical Update Christopher Smith (USA) |
Prosectors: Timothy Greco (USA) Peter Palhazi (Hungary) Discussants: Steven G. Yoelin (USA) Wendy Lee (USA) |
What to Say to a Newly Diagnosed Patient and How to Manage Expectations Marie-Helene Marion (UK) How to Advise a Patient with CD: Exercise, Daily Living, Retraining Lena Zetterberg (Sweden) Strategy for Starting BoNT Treatment (written consent, initial dose and subsequent doses, interval, follow-up) Joseph Tsui (Canada) |
From Benchmark to the Latest Clinical Data: Evidence for the Use of BoNT in the Upper Extremity Jorg Wissel (Germany) Evidence for the Use of BoNT in the Lower Extremity Allison Brashear (USA) |
Oromandibular and Laryngeal Dystonia Andrew Blitzer (USA) |
Hands-on Ultrasound Guidance – Upper Extremity Katherine Alter (USA) Florian Heinen (Germany) Barbara Karp (USA) Heakyung Kim (USA) Serdar Kocer (Switzerland) David Simpson (USA) |
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| 15:00 – 15:30 | Discovery of Novel Botulinum Therapeutics: A Binary Approach Bazbek Davletov (UK) |
The Comprehensive Approach to The Management of Spasticity: Chemodenervation and Adjunctive Therapies Jean-Michel Gracies (France) |
Dystonic Swallowing, Speech and Breathing Difficulties: What the Injector Needs to Know Lucy Hicklin (UK) |
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| 15:30 – 16:00 | Chimeras of Anthrax Toxin and Botulinum Neurotoxin as Novel Analgesic Proteins Nicole Yang (USA) Botulinum Neurotoxin B Engineered for Increased Receptor Affinity Has Improved Clinical Potential Johannes Krupp (UK) |
Cervical Dystonia in Rotation: Different Injection Protocols for Different Clinical Phenotypes Video Case Studies Speaker: Joseph Jankovic (USA) |
Challenging Patients with Progressive Spastic Paraparesis: Multiple Hospitals, Changing Neurotoxin Preparations: How Do You Maintain a Patient’s Standard of Care? Francesco Scaglione (Italy) The Anticoagulated Patient: Management Challenges Chris Boulias (Canada) |
Lip and Tongue Dystonia: “Drooling Along the Way” Raymond Rosales (Philippines) |
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| 1 Selected Abstract | |||||||||
| 16:00 – 16:30 | BREAK | BREAK | BREAK | BREAK | BREAK | BREAK | BREAK | ||
| PARALLEL TRACKS | Basic Science Track | Clinical Track 1B | Clinical Workshop 1B | Clinical Workshop 2B | Clinical Workshop 3B | Clinical Workshop 4B | Clinical Workshop 5B | ||
| 16:30 – 18:30 | Mode of Action of BoNTs Co-chairs: Mauricio Montal (USA) Thomas Binz (Germany) |
Other Neurological Uses for BoNT Session Chair: Francisco Cardoso (Brazil) |
Cosmetic and Dermatologic Uses Moderator: Steven G. Yoelin (USA) |
Cervical Dystonia Injection Workshop I Moderator: Carlos Singer (USA) |
Adult Spasticity Injection Workshop Moderator: Anthony Ward (UK) |
Oromandibular Dystonia and Spasmodic Dysphonia Injection Workshop Moderator: Stewart Factor (USA) |
Hands-on Ultrasound Guidance Hands-on Workshop Session Chair: Katherine Alter (USA) Learn more |
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| 16:30 – 17:00 | Structural Insights into BoNT Receptor Interaction or Into BoNT Complexes Richard Kammerer (Switzerland) |
Management of Sialorrhea Wolfgang Jost (Germany) |
2 Selected Abstracts | Demonstrations on Live Patients Master Injector: Torben Dalager (Denmark) |
Demonstrations on Live Patients Master Injector: Bo Biering-Sørensen (Denmark) |
Demonstrations on Live Patients Master Injector: Gohar Nikoghosyan-Bossen (Denmark) Master Injector: Heidi Bryde Biernat (Denmark) |
Hands-on Ultrasound Guidance – Lower Extremity Katherine Alter (USA) Florian Heinen (Germany) Barbara Karp (USA) Heakyung Kim (USA) Serdar Kocer (Switzerland) |
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| 17:00 – 17:30 | Mutations in Light Chain of Botulinum Neurotoxin A Enable Cleavage of Human Snap-23 Thomas Binz (Germany) The Structure of the Tetanus Toxin Reveals pH-Mediated Domain Dynamics Geoffrey Masuyer (Sweden) |
The Utility of BoNT in Parkinson’s–Beyond Sialorrhea Fernando Pagan (USA) |
Injection Workshop I – Demonstrations on Live Patients Master Injector: Jesper Thulesen (Denmark) |
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| 17:30 – 18:00 | Basic Biology of BoNTs Suzanne Kalb (USA) |
1 Selected Abstract Botulinum Toxin for the Treatment of Hand Tremor Nicki Niemann (USA) |
OnabotulinumtoxinA Treatment Utilization Varies by Etiology of Spasticity, While Maintaining High Patient and Clinician Satisfaction: Results from the Aspire Study Gerard E. Francisco (USA) 1 Selected Abstract |
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| 18:00 – 18:30 | Identification and Characterization of a Botulinum Neurotoxin–Like Toxin in a Commensal Strain of Enterococcus faecium Michael J. Mansfield (Canada) Novel Aspects of Intestinal Botulism Francois Douillard (Finland) |
| Friday, 18 January, 2019 | |
|---|---|
| 07:00 – 08:30 | Registration/ Information |
| 07:00 – 08:30 | Exhibits & Breakfast |
| 08:30 – 12:00 | Plenary Session Duration of Action Co-chairs: Matteo Caleo (Italy) David Simpson (USA) |
| 08:30 – 09:00 | Clinical Duration of Action of Different Toxin Types Roberto Eleopra (Italy) |
| 09:00 – 09:30 | Came to Stay: Receptor Interactions of Botulinum Neurotoxins Andreas Rummel (Germany) |
| 09:30 – 10:00 | Are Booster Injections Safe? Dirk Dressler (Germany) |
| 10:00 – 10:30 | Break |
| 10:30 – 11:00 | Cell Entry, Activation and Intracellular Persistence of BoNT Light Chains Marco Pirazzini (Italy) |
| 11:00 – 11:30 | Synaptic and Central Mechanisms Contributing to Duration (BoNT Trafficking in Neurons) Fred Meunier (Australia) |
| 11:30 – 12:00 | Duration of Action in Dermatology/Aesthetics Nowell Solish (Canada) |
| 12:00 – 13:30 | Lunch |
| 12:00 – 14:30 | Exhibits |
| 12:00 – 14:30 | Poster Session |
| PARALLEL TRACKS | Basic Science Track | Clinical Workshop 1A | Clinical Workshop 2A | Clinical Workshop 3A | Clinical Workshop 5A | Clinical Workshop 6A | ||
|---|---|---|---|---|---|---|---|---|
| 14:30 – 16:00 | Neuronal Plasticity and Trafficking of BoNTs Co-chairs: Ornella Rossetto (Italy) Yukako Fujinaga (Japan) |
Pediatric Spasticity and Movement Disorders Session Chair: Florian Heinen (Germany) |
Cosmetic and Dermatologic Applications of Botulinum Toxin Session Chair: Steven G. Yoelin (USA) |
Cervical Dystonia II Session Chair: Ryuji Kaji (Japan) |
Hemifacial Spasm and Blepharospasm Session Chair: Marie Vidailhet (France) |
Hands-on Ultrasound Guidance Hands-on Workshop Session Chair: Katherine Alter (USA) Learn more |
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| 14:30 – 15:00 | Neuronal Selectivity of BoNTs Michel Popoff (France) |
Review of Common Gait Patterns in Children With Cerebral Palsy Mark Gormley (USA) |
“Classic” Cosmetic Use of Botulinum Toxins: From Glabella to Platysma: Injection Techniques to Maximize Outcomes Timothy Greco (USA) |
Anterocollis Posture and Deep Cervical Muscle Injections With BoNT Laxman Bahroo (USA) |
The Patient’s Perspective: Personal Experience, Psychological Profile and Social Media Marie Vidailhet (France) |
Hands-on Ultrasound Guidance – Upper Extremity Katherine Alter (USA) Barbara Karp (USA) Heakyung Kim (USA) Serdar Kocer (Switzerland) Michael Munin (USA) |
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| 15:00 – 15:30 | Neuronal Plasticity and BoNTs as Pain Therapeutics Stephen Hunt (UK) |
Neurotoxin Therapy vs Physical Treatments: What Is the Optimal Approach for the Pediatric Patient? Henk Stam (Netherlands) |
Challenging Botulinum Toxin Cases, Bridging Cosmetic and Therapeutic Nowell Solish (Canada) Last 15 Minutes – Ask the Experts Open Forum Discussion |
Cervical Dsytonia Revisited Alberto Albanese (Italy) |
Blepharospasm and Hemifacial Spasm: Different Injection Protocols for Different Clinical Phenotypes Video Case Studies Marie-Helene Marion (UK) |
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| 15:30 – 16:00 | Exploring the Effect of Various BoNT Serotypes in a Model of Autonomic Nervous System Hyperactivity From Rodents and Humans: Paving the Way to Better Targeting Therapeutics in Autonomic Disorders? Jacquie Maignel (France) Centrally Transported Botulinum Toxin Type A Relieves Local Spastic Paralysis Ivica Matak (Croatia) |
Where do ‘Toxins’ fit in the Care Pathway of Pediatric Dystonia and Cerebral Palsy? Darcy Fehlings (Canada) |
Outcomes of Week-24 Completers and Subjects Who Had Follow-Up Beyond Week 24 After a Single Treatment of Daxibotulinumtoxina for Injection (Rt002): Results of a Phase 2, Open-Label (Level II), Dose-Escalating Study in Isolated Cervical Dystonia Atul Patel (USA) Management Algorithm for Bont Injections with Electromyography and Ultrasound Guidance in Cervical Dystonia Anna Castagna (Italy) |
Facial Tics Joseph Jankovic (USA) |
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| 16:00 – 16:30 | BREAK | BREAK | BREAK | BREAK | BREAK | BREAK | ||
| PARALLEL TRACKS | Basic Science Track | Clinical Workshop 1B | Clinical Workshop 2B | Clinical Workshop 3B | Clinical Workshop 4 | Clinical Workshop 5B | Clinical Workshop 6B | |
| 16:30 – 18:30 | Protection and Detection Co-chairs: Sabine Pellett (USA) Sheng Chen (China) |
Pediatric Spasticity Moderator: Cindy Ivanhoe (USA) |
Focal Limb Dystonia Injection Workshop Moderator: David Simpson (USA) |
Cervical Dystonia Injection Workshop II Moderator: Alberto Albanese (Italy) |
Primary Headache Session Chair: Cristina Tassorelli (Italy) |
Hemifacial, Blepharospasm and Sialorrhea Injection Workshop Moderator: Raymond Rosales (Philippines) |
Hands-on Ultrasound Guidance Hands-on Workshop Session Chair: Katherine Alter (USA) Learn more |
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| 16:30 – 17:00 | The Development of Catalytically Inactive Botulinum Neurotoxin Holoproteins Robert Webb (USA) |
1 Selected Abstract | Focal Limb Dystonia and Tremor: Clinical Update Mandar Jog (Canada) |
Demonstrations on Live Patients Master Injector: Theódora Hannesdóttir Cleemann (Denmark) |
Pathophysiology of Migraine: Migraine Pain vs Other Types of Chronic Pain–Similarities and Differences Anthony Dickenson (UK) |
Demonstrations on Live Patients Master Injector: Heidi Bryde Biernat (Denmark) |
Hands-on Ultrasound Guidance – Head and Neck Katherine Alter (USA) Barbara Karp (USA) Heakyung Kim (USA) Serdar Kocer (Switzerland) Michael Munin (USA) |
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| 17:00 – 17:30 | RNA-Based Therapeutics Chuck Shoemaker (USA) |
Video Case Studies Presented by: Florian Heinen (Germany) Cindy Ivanhoe (USA) Sebastian Schroeder (Germany) |
Focal Limb Dystonia Injection Workshop Moderator: Mark Hallett (USA) |
Predictors of Response to BoNT in Chronic Migraine Patricia Pozo-Rosich (Spain) |
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| 17:30 – 18:00 | Small Molecule Inhibitors to BoNTs Kim Janda (USA) |
Demonstrations on Live Patients Master Injector: Torben Dalager (Denmark) |
Demonstrations on Live Patients Master Injector: Sonja Antic (Denmark) |
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| 18:00 – 18:30 | Development of an In Vitro Human Neuromuscular Junction Camille Nicoleau (France) Catwalk™ as a Functional Analysis Tool of Rodents Injected With Botulinum Neurotoxin Sabine Pellett (USA) |
| Saturday, 19 January, 2019 | |
|---|---|
| 07:00 – 12:00 | Registration/ Information |
| 07:00 – 08:30 | Exhibits |
| 09:00 – 11:15 | Plenary Session |
| 08:00 – 09:00 | INA Members Business Meeting |
| 09:00 – 11:15 | New Toxins Chair: Giampietro Schiavo (UK) |
| 09:00 – 09:30 | What Properties do Clinicians and Patients Want? Jörg Wissel (Germany) |
| 09:30 – 10:00 | Family of BoNTs and New Toxins Pål Stenmark (Sweden) |
| 10:00 – 10:30 | New Versions of BoNT Including Transdermal Preparations and Type E: New Clinical Indications: Ongoing Clinical Trials Cynthia Comella (USA) |
| 10:30 – 11:00 | Toxin Engineering Min Dong (USA) |
| 11:00 – 11:15 | Conference Closing Remarks Cynthia Comella (USA) |
