| Wednesday, January 14, 2015 | |
| All Day | Exhibit Setup |
| 10:00 – 19:00 | Registration Open |
| 10:00 – 19:00 | Poster Setup |
| 18:30 – 18:40 | Welcome and Opening Remarks Mark Hallett (Bethesda, MD, USA) Alberto Albanese (Milan, Italy) |
| 18:40 – 19:30 | Lifetime Achievement Award Ceremony |
| 19:30 – 21:30 | Welcome Reception |
| Thursday, January 15, 2015 | |
| 07:00 – 18:30 | Registration/Information |
| 07:00 – 08:30 | Exhibits |
| Plenary Session – Mechanisms of Action Chairs: Giampietro Schiavo (London, UK) and Cynthia Comella (Chicago, IL, USA) |
|
| 08:30 – 08:45 | Welcome and Opening Remarks Alberto Albanese (Milan, Italy) Mark Hallett (Bethesda, MD, USA) |
| 08:45 – 09:45 | Keynote Presentation – Cell Biology of the Neuron: Membrane Lipid Dynamics in the Regulation of Synaptic Function Pietro De Camilli (New Haven, CT, USA) |
| 09:45 – 10:20 | Explanation of Timing of Botulinum Neurotoxin (BoNT) Effects, Onset, and Duration and Clinical Ways of Influencing Them Mark Hallett (Bethesda, MD, USA) |
| 10:20 – 10:50 | Break |
| Plenary Session – Mechanisms of Action Chairs: Cynthia Comella (Chicago, IL, USA) and Hans Bigalke (Hannover, Germany) |
|
| 10:50 – 11:25 | BoNT Complexes and Their Journey Toward the Nervous System Andreas Rummel (Hannover, Germany) |
| 11:25 – 12:00 | Clinical Comparison of Effects at Neuromuscular Junction and Autonomic Nerves: Similarities and Differences Markus Naumann (Augsburg, Germany) |
| 12:00 – 13:45 | Lunch |
| 12:00 – 14:30 | Exhibits |
| 12:00 – 14:30 | Poster Session |
| Participants will break into separate groups for Basic Science, Clinical, Workshop A, Workshop B, Workshop C, and Workshop D sessions. | |
| Parallel Track I (Basic Science) | |
| 14:30 – 15:45 | Genetics and Evolution Chair: Eric Johnson (Madison, WI, USA) |
| 14:30 – 15:00 | Genomics and Evolution of Clostridium botulinum and Its Neurotoxins Michael Peck (Norwich, UK) |
| 15:00 – 15:30 | The Genetic Diversity of Clostridium botulinum and Its Neurotoxins Karen Hill (Los Alamos, NM, USA) |
| 15:30 – 15:45 | Functional Characterization of a Novel Botulinum Neurotoxin F/A Hybrid Suzanne R. Kalb (Atlanta, GA, USA) |
| 15:45 – 16:15 | Break |
| 16:15 – 18:30 | Molecular Interactions Chair: Thomas Binz (Hannover, Germany) |
| 16:15 – 16:45 | Dissecting the Sophisticated Host-BoNT Interplay in the Gastrointestinal Tract Rongsheng Jin (Irvine, CA, USA) |
| 16:45 – 17:15 | Disassociation Mechanism of Progenitor Complex of Botulinum Neurotoxin Serotype E Subramanyam Swaminathan (Upton, NY, USA) |
| 17:15 – 17:45 | Structural Studies of the Binding of the Botulinum Neurotoxins to Protein and Ganglioside Receptors Pål Stenmark (Stockholm, Sweden) |
| 17:45 – 18:00 | Botulinum Neurotoxin A Complex Exploits Intestinal M Cells to Enter the Host Yukako Fujinaga (Osaka, Japan) |
| 18:00 – 18:15 | Thioredoxin and Its Reductase Are Present on Synaptic Vesicles and Their Inhibition Prevents the Paralysis Induced by Botulinum Neurotoxins Marco Pirazzini (Padua, Italy) |
| 18:15 – 18:30 | Nidogens Are Therapeutic Targets for the Prevention of Tetanus Kinga Bercsenyi (London, UK) |
| Parallel Track I (Clinical) | |
| 14:30 – 16:00 | Initial and Subsequent Injections: How Do We Modify the Approach to Optimize Outcomes? Chair: Diego R. Torres-Russotto (Omaha, NE, USA) |
| 14:30 – 15:00 | Cervical Dystonia Alberto Espay (Cincinnati, OH, USA) |
| 15:00 – 15:30 | Writer’s Cramp Barbara Karp (Bethesda, MD, USA) |
| 15:30 – 16:00 | Blepharospasm Diego R. Torres-Russotto (Omaha, NE, USA) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:00 | Measuring Outcomes of BoNT Therapy for Dystonia Chair: Alberto Albanese (Milan, Italy) |
| 16:30 – 17:00 | Development of a Rating Scale Glenn Stebbins (Chicago, IL, USA) |
| 17:00 – 17:30 | Focal Dystonia: Rating Scales Alberto Albanese (Milan, Italy) |
| 17:30 – 18:00 | Spasticity: Rating Scales Allison Brashear (Winston-Salem, NC, USA) |
| Parallel Track II (Clinical) |
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| 14:30 – 16:10 | Application of BoNT for the Treatment of Cerebral Palsy Chair: Ann Tilton (New Orleans, LA, USA) |
| 14:30 – 14:55 | Evidence-Based Review of Safety and Efficacy in Cerebral Palsy Ann Tilton (New Orleans, LA, USA) |
| 14:55 – 15:20 | Optimizing Outcomes With Adjunctive Therapy Anthony Ward (Stoke-on-Trent, UK) |
| 15:20 – 15:45 | Special Considerations: Dosing Limits and Reasons that Children Discontinue Therapy Florian Heinen (Munich, Germany) |
| 15:45 – 16:10 | Managing Drooling in Cerebral Palsy Steffen Berweck (Vogtareuth, Germany) |
| 16:10 – 16:30 | Break |
| 16:30 – 18:00 | Approach to Spasticity Using Botulinum Toxin Chair: Cindy Ivanhoe (Houston, TX, USA) |
| 16:30 – 17:00 | Management of Spasticity: Where Does BoNT Fit? Nathaniel Mayer (Elkins Park, PA, USA) |
| 17:00 – 17:30 | Maximizing Outcomes in Spasticity Using BoNT Cindy Ivanhoe (Houston, TX, USA) |
| 17:30 – 18:00 | Adjunctive Treatments for Spasticity Joaquim Ferreira (Lisbon, Portugal) |
| Parallel Track – Clinical (Workshop A) | |
| 14:30 – 18:30 | Treatment of Laryngeal Disorders and Oromandibular Dystonia Chair: Andrew Blitzer (New York, NY, USA) |
| 14:30 – 15:00 | Evidence-Based Review: Abductor, Adductor, Vocal Tremor Allen Hillel (Seattle, WA, USA) |
| 15:00 – 15:30 | Techniques for Injection Localization and Dosing Andrew Blitzer (New York, NY, USA) |
| 15:30 – 16:00 | Oromandibular Dystonia Raymond Rosales (Manila, Philippines) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:30 | Demonstrations on Video and Live Patients Miguel Coelho (Portugal) Andrew Blitzer (New York, NY, USA) Raymond Rosales (Manila, Philippines) Allen Hillel (Seattle, WA, USA) |
| Parallel Track – Clinical (Workshop B) | |
| 14:30 – 18:30 | Use of BoNT for Bladder Conditions Chair: Michael Chancellor (Royal Oak, MI, USA) |
| 14:30 – 15:00 | Functional Anatomy of the Genitourinary Tract Christopher Smith (Houston, TX, USA) |
| 15:00 – 15:30 | Introduction to Use of Botulinum Toxin for Genitourinary Conditions (Which Conditions, What Evidence?) Michael Chancellor (Royal Oak, MI, USA) |
| 15:30 – 16:00 | Injection Techniques Francisco Cruz (Barquinha, Portugal) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:30 | Video and Pelvic Model Demonstrations Michael Chancellor (Royal Oak, MI, USA) Christopher Smith (Houston, TX, USA) Francisco Cruz (Barquinha, Portugal) |
| Parallel Track – Clinical (Workshop C) | |
| 14:30 – 18:30 | Cosmetic Uses of Botulinum Toxin Chair: Ellen Gendler (New York, NY, USA) |
| 14:30 – 15:00 | Introduction to the Anatomy of Facial Aesthetics Jonathan Sykes (Sacramento, CA, USA) |
| 15:00 – 15:30 | BoNT Injections of the Face: Options and Outcomes Ellen Gendler (New York, NY, USA) |
| 15:30 – 16:00 | BoNT Injections for Hyperhidrosis: Efficacy and Side Effects Dee Anna Glaser (St. Louis, MO, USA) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:30 | Demonstrations on Live Patients João Maia Silva (Portugal) Miguel Correia (Portugal) Rui Oliveira Soares (Portugal) Ellen Gendler (New York, NY, USA) Dee Anna Glaser (St. Louis, MO, USA) Jonathan Sykes (Sacramento, CA, USA) |
| Parallel Track – Clinical (Workshop D) | |
| 14:30 – 16:00 | Techniques for Localizing Muscles for BoNT Injection: Demonstration Workshop Chair: Erle Lim (Singapore) |
| 14:30 – 15:00 | EMG Marina de Koning-Tijssen (Groningen, Netherlands) |
| 15:00 – 15:30 | Ultrasound Katharine Alter (Bethesda, MD, USA) |
| 15:30 – 16:00 | Other Techniques, Including Inspection, Palpation, Anatomic Landmarks Erle Lim (Singapore) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:00 | Treatment of Tremor With BoNT Chair: Dirk Dressler (Hannover, Germany) |
| 16:30 – 17:00 | Approach to Hand Tremors Seth Pullman (New York, NY, USA) |
| 17:00 – 17:30 | Head Tremor Wolfgang Jost (Wiesbaden, Germany) |
| 17:30 – 18:00 | Voice Tremor Robert Bastian (Downers Grove, IL, USA) |
| Friday, January 16, 2015 | |
| 07:00 – 18:30 | Registration/Information |
| 07:00 – 08:30 | Exhibits |
| Plenary Session – The Botulinum Neurotoxins Chairs: Cesare Montecucco (Padua, Italy) and Francisco Cardoso (Minas Gerais, Brazil) |
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| 08:30 – 09:10 | Structure of the BoNT/A Receptor Complex Richard A. Kammerer (Villigen PSI, Switzerland) |
| 09:10 – 09:45 | Differences in Mode of Action of the Different Toxins Sabine Pellett (Madison, WI, USA) |
| 9:45 – 10:20 | Clinical Differences Between Type A and B Toxins Anna Rita Bentivoglio (Rome, Italy) |
| 10:20 – 10:50 | Break |
| 10:50 – 11:25 | Clinical Differences Between A1 and A2 Botulinum Toxin Subtypes Ryuji Kaji (Tokushima, Japan) |
| 11:25 – 12:00 | Ganglioside Trafficking and Antiganglioside Antibodies Hugh Willison (Glasgow, UK) |
| 12:00 – 13:45 | Lunch |
| 12:00 – 14:30 | Exhibits |
| 12:00 – 14:30 | Poster Session |
| Participants will break up into separate groups for Basic Science, Clinical, Workshop A, Workshop B, Workshop C, and Workshop D sessions. | |
| Parallel Track I (Basic Science) | |
| 14:30 – 16:00 | Toxin Trafficking Chair: Mauricio Montal (La Jolla, CA, USA) |
| 14:30 – 15:00 | Multiple Domains of Tetanus Toxin Direct Entry into Primary Neurons Joseph Barbieri (Milwaukee, WI, USA) |
| 15:00 – 15:30 | Variations in VAMP1 Across Vertebrates Suggest a Potential Selective Pressure From Botulinum Neurotoxins Min Dong (Southborough, MA, USA) |
| 15:30 – 16:00 | The Long Duration of Action of Clostridium botulinum A5 Toxin at the Mammalian Neuromuscular Junction M. Jordi Molgó (Paris, France) |
| 16:00 – 16:30 | Break |
| 16:30 – 17:30 | Immunity and Immunoprotection Chair: Dorothea Sesardic (London, UK) |
| 16:30 – 17:00 | Human Antibody Engineering for Prevention and Treatment of Botulinum Neurotoxin (BoNT) Intoxication Jianlong Lou (San Francisco, CA, USA) |
| 17:00 – 17:30 | VNAs as Unconventional and Versatile Therapeutics for Toxin-Mediated Diseases Charles Shoemaker (Medford, MA, USA) |
| 17:30 – 18:15 | Toxin Detection Chair: Leonard Smith (Fort Detrick, MD, USA) |
| 17:30 – 18:00 | Shining the Light on Botulism: Enzyme Acceleration, Fluorescent and Bioluminescent Toxin Detection Markus Kalkum (Duarte, CA, USA) |
| 18:00 – 18:15 | Broad-Spectrum Detection of All Clostridial Neurotoxins in Stem Cell-Derived Neurons and Identification of Compounds That Rescue Synaptic Activity in Synaptic Function-Based Assays Patrick McNutt (Fallston, MD, USA) |
| Parallel Track I (Clinical) | |
| 14:30 – 16:00 | Clinical Pearls: Optimizing Outcomes in Blepharospasm and Hemifacial Spasm Chair: Giovanni DeFazio (Bari, Italy) |
| 14:30 – 15:00 | Diagnosis of Blepharospasm: Are We There Yet? Giovanni DeFazio (Bari, Italy) |
| 15:00 – 15:30 | Is There One Toxin/Dose That is Superior to Another for Blepharospasm/Hemifacial Spasm (HFS)? Anna Rita Bentivoglio (Rome, Italy) |
| 15:30 – 16:00 | How to Inject for Optimal Outcome Earl Consky (Toronto, Canada) |
| 16:00 – 16:30 | Break |
| 16:30 – 17:00 | Platform Session − Long-Term Studies of BoNT Efficacy, Safety, and Responsiveness Chairs: Giovanni DeFazio (Bari, Italy) and Peter Moore (Liverpool, UK) |
| 16:30 – 16:40 | Treatment Patterns and Patient Disposition in the Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy (CD PROBE) Cynthia Comella (Chicago, IL, USA) |
| 16:40 – 16:50 | Efficacy of IncobotulinumtoxinA in Poststroke Upper Limb Spasticity: Results From a Large Multicenter 1-Year Noninterventional Study Dirk Dressler (Hannover, Germany) |
| 16:50 – 17:00 | Botulinum Toxin in Sialorrhea Is Safe and Effective in Long-Term Use Martina Petracca (Rome, Italy) |
| 17:00 – 18:30 | Considerations When Botulinum Toxin Treatment Is Not Effective Chair: Peter Moore (Liverpool, UK) |
| 17:00 – 17:30 | The Many Causes of Secondary Nonresponse Cynthia Comella (Chicago, IL, USA) |
| 17:30 – 18:00 | Molecular Basis of Immunogenicity to Botulinum Neurotoxins M. Zouhair Atassi (Houston, TX, USA) |
| 18:00 – 18:30 | Assessing Antibodies to Botulinum Toxin Dirk Dressler (Hannover, Germany) |
| Parallel Track II Clinical |
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| 14:30 – 16:00 | Gait Lab: Functional Evaluation of Gait for Muscle Selection in Spasticity Patients Chair: Alberto Esquenazi (Elkins Park, PA, USA) |
| 14:30 – 15:00 | A New Symptom-Based Approach to Neurological Gait Disorders Alberto Esquenazi (Elkins Park, PA, USA) |
| 15:00 – 15:30 | Effects of Botulinum Toxin Treatment on Dystonic and Spastic Gait Anja Van Campenhout (Pellenberg, Belgium) |
| 15:30 – 16:00 | Use of Gait Lab Studies in Lower Extremity Dystonia to Identify Muscles for Injection Katharine Alter (Bethesda, MD, USA) |
| 16:00 – 16:30 | Break |
| 16:30 – 17:00 | Platform Presentations: Applications of Botulinum Toxin for Complicated Neurological Conditions: Chair: Francisco Cardoso (Minas Gerais, Brazil) |
| 16:30 – 16:40 | Botulinum Toxin Type A (incobotulinumtoxinA) for Muscle Cramps Associated With Diabetic Neuropathy: A Double-Blind, Placebo-Controlled Study Domenico Antonio Restivo (Catania, Italy) |
| 16:40 – 16:50 | OnabotulinumtoxinA Improves Pain in Poststroke Spasticity Patients: Findings from a Randomized Controlled Trial Jörg Wissel (Berlin, Germany) |
| 16:50 – 17:00 | Efficacy and Safety Profile of IncobotulinumtoxinA in Children With Cerebral Palsy: Randomized Double-Blind Clinical Trial Elena Carraro (Treviso, Italy) |
| 17:00 – 18:30 | Botulinum Toxin in Nondystonic Disorders Chair: Francisco Cardoso (Minas Gerais, Brazil) |
| 17:00 – 17:30 | Botulinum Toxin for Hemiparetic Gait Alberto Esquenazi (Elkins Park, PA, USA) |
| 17:30 – 18:00 | Tremor: Essential Tremor and Palatal Tremor Hrishikesh Kumar (Kolkata, India) |
| 18:00 – 18:30 | Parkinson’s Disease – Clinical Aspects That Can Be Treated With Botulinum Toxin Francisco Cardoso (Minas Gerais, Brazil) |
| Parallel Track (Workshop A) | |
| 14:30 – 18:30 | Botulinum Toxin for Headache Chair: Stephen Silberstein (Philadelphia, PA, USA) |
| 14:30 – 15:00 | Evidence-Based Review of BoNT for Headache Alan Finkel (Chapel Hill, NC, USA) |
| 15:00 – 15:30 | Mechanism of Effect in Headache Michael Oshinsky (Philadelphia, PA, USA) |
| 15:30 – 16:00 | Clinical Pearls for Optimal Outcome Stephen Silberstein (Philadelphia, PA, USA) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:30 | Case Studies: Injection Techniques for Headache Live Patients and Models Isabel Pavão Martins (Portugal) Alan Finkel (Chapel Hill, NC, USA) Michael Oshinsky (Philadelphia, PA, USA) Stephen Silberstein (Philadelphia, PA, USA) |
| Parallel Track (Workshop B) | |
| 14:30 – 16:00 | Controversies and Unresolved Issues in Use of BoNT Chair: Daniel Truong (Fountain Valley, CA, USA) |
| 14:30 – 15:00 | Camptocormia Carlo Colosimo (Rome, Italy) |
| 15:00 – 15:30 | Pain Other Than Headache Bahman Jabbari (New Haven, CT, USA) |
| 15:30 – 16:00 | Anterocollis Josef Finsterer (Vienna, Austria) |
| 16:00 – 16:30 | Break |
| 16:30 – 17:00 | Platform Session – Use of BoNT in Nondystonic Disorders Chairs: Daniel Truong (Fountain Valley, CA, USA) and Bernhard Voller (Vienna, Austria) |
| 16:30 – 16:40 | Consistent Long-Term Efficacy and Safety of Repeat OnabotulinumtoxinA Injections in Patients With Neurogenic Detrusor Overactivity: Final Results of Up to 4 Years’ Treatment Karen Ethans (Winnipeg, Manitoba, Canada) |
| 16:40 – 16:50 | AbobotulinumtoxinA in the Treatment of Adults With Upper Limb Spasticity in a Randomized, Double-Blind, Placebo-Controlled Study Jean-Michel Gracies (Créteil, France) |
| 16:50 – 17:00 | An Exploratory, Single-Center, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, 16-Week Study of the Efficacy and Safety of Intra-Articular OnabotulinumtoxinA (OnabotA, 200 U) as Treatment for Osteoarthritis Knee Pain: Results from Experimental Pain Models Lars Arendt-Nielsen (Jutland, Denmark) |
| Parallel Track (Workshop C) | |
| 14:30 – 18:30 | Treatment of Focal, Task-Specific Dystonias Chair: Charles Adler (Scottsdale, AZ, USA) |
| 14:30 – 15:00 | Musician’s Dystonia Steven Frucht (New York, NY, USA) |
| 15:00 – 15:30 | Writer’s Cramp Jennifer Goldman (Chicago, IL, USA) |
| 15:30 – 16:00 | Laryngeal Dystonia Charles Adler (Scottsdale, AZ, USA) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:30 | Video Demonstrations and Live Patients Miguel Coelho (Portugal) Steven Frucht (New York, NY, USA) Jennifer Goldman (Chicago, IL, USA) Charles Adler (Scottsdale, AZ, USA) |
| Parallel Track (Workshop D) | |
| 14:30 – 18:30 | Practical Applications for Cervical Dystonia, Blepharospasm, and Spasticity – Video Demonstrations and Live Patient Injections Chair: Joaquim Ferreira (Lisbon, Portugal) |
| 14:30 – 15:30 15:30 – 16:30 16:30 – 17:00 17:00 – 18:00 18:00 – 18:30 |
Spasticity Allison Brashear (Winston-Salem, NC, USA) Jorge Jacinto (Portugal) Session I Session II Break Session III Q&A |
| 14:30 – 15:30 15:30 – 16:30 16:30 – 17:00 17:00 – 18:00 18:00 – 18:30 |
Cervical Dystonia Richard Barbano (Rochester, NY, USA) Patrícia Lobo (Portugal) Session I Session II Break Session III Q&A |
| 14:30 – 15:30 15:30 – 16:30 16:30 – 17:00 17:00 – 18:00 18:00 – 18:30 |
Blepharospasm Karen Frei (Loma Linda, CA, USA) Anabela Valadas (Portugal) Session I Session II Break Session III Q&A |
| Saturday, January 17, 2015 | |
| 07:00 – 12:30 | Registration/Information |
| 07:00 – 09:00 | Exhibits |
| Plenary Session – The Future Chairs: Mark Hallett (Bethesda, MD, USA) and Andreas Rummel (Hannover, Germany) |
|
| 08:15 – 9:00 | INA Business Meeting |
| 09:00 – 09:30 | Depression M. Axel Wollmer (Hamburg, Germany) |
| 09:30 – 10:00 | Pain, Sensory System, Central Effects Peter Goadsby (San Francisco, CA, USA) |
| 10:00 – 10:30 | Shortened Intervals Between Injections Hubert Fernandez (Cleveland, OH, USA) |
| 10:30 – 11:00 | Break |
| 11:00 – 11:30 | Gaps in Basic Knowledge Cesare Montecucco (Padua, Italy) |
| 11:30 – 12:00 | Long-term Clinical Effects Joseph Jankovic (Houston, TX, USA) |
| 12:00 – 12:15 | Closing Remarks Joseph Jankovic (Houston, TX, USA) |