Conference Program

Satellite-Symposia-Schedule-smaller

 

 

Download TOXINS 2017 Program Schedule at a Glance

Wednesday, 18 January, 2017
All Day Exhibit Setup
10:00 – 18:00 Registration Open
10:00 – 18:00 Poster Setup
Auditorium and Castilla
18:00 – 18:30 Welcome and Opening Remarks and Lifetime Achievement Award Ceremony
Joseph Jankovic (USA)
Alberto Albanese (Italy)
18:30-19:00 Unexpected Consequences
Mark Hallett (USA)
19:00 – 19:30 DasGupta Memorial Lecture:
Cesare Montecucco (Italy)
19:30 – 22:00 Welcome Reception – Tapices Room
Thursday, 19 January, 2017
07:00 – 18:30 Registration / Information
07:00 – 08:30 Exhibits (Patio Areas)
Plenary Session – Auditorium and Castilla
08:30 – 08:40 Welcome and Opening Remarks and Introduction of Keynote Speaker
Andreas Rummel (Germany)
08:40 – 09:30 Keynote Presentation – Presynaptic Functions
Erik M. Jorgensen (USA)
09:30 – 10:00 Assembly and Disassembly of the SNARE Complex
Axel Brunger (USA)
10:00 – 10:30 What’s the Best Dosage and Interval for BoNT Injections in Dystonia and Spasticity Treatment?
Jörg Wissel (Germany)
10:30 – 11:00 Break
11:00 – 11:30 Recent Developments in Clinical Trials of BoNT
Alberto Albanese (Italy)
11:30 – 12:00 Advances in the Architecture of the BoNT Complex
Rongsheng Jin (USA)
12:00 – 13:30 Lunch (Patio Areas)
12:00 – 14:30 Exhibits (Patio Areas)
12:00 – 14:30 Poster Session (Patio Areas)
Participants will break into separate groups for Basic Science, Clinical, Workshops A, and Workshops B.
Parallel Track I (Basic Science) Auditorium
14:30 – 16:00 Genetics and Evolution
Session Chair: Cesare Montecucco (Italy)
14:30 – 15:00 Regulation of C. Botulinum Growth and Toxin Production
Miia Lindström (Finland)
15:00 – 15:30 Botulinum Neurotoxin Homologs in Non-Clostridial Species
Andrew Doxey (Canada)
15:30 – 15:45 Identification And Characterization Of A Novel Botulinum Neurotoxin
Pål Stenmark (Sweden)
15:45 – 16:00 A Functional Assay Devoid of Antibodies For Serotyping and Detection of Botulinum Neurotoxins
Jasmin Weisemann (Germany)
16:00 – 16:30 Break
16:30 – 18:30 Molecular Interactions I
Session Chair: Giampietro Schiavo (UK)
16:30 – 17:00 Binding of BoNT to Glycosylated SV2
Stefan Mahrhold (Germany)
17:00 – 17:30 Botulinum Neurotoxin Type A Enters a Non-Recycling Pool of Synaptic Vesicles
Frederic Meunier (Australia)
17:30 – 18:00 Botulinum Neurotoxins Inhibit Cytokine-Induced Trafficking of TRPV1 and A1 in Cultured Sensory Neurons
Oliver Dolly (Ireland)
18:00 – 18:30 Translocation and Dissemination to Target Neurons of Botulinum Neurotoxin Type B in the Mouse Intestinal Wall
Michel R. Popoff (France)
Clinical Tracks 1A & 1B – Castilla Room
14:30 – 16:00 Oromandibular Dystonia
Session Chair: Cynthia Comella (USA)
14:30 – 15:00 Pathophysiology and Clinical Features
Ryuji Kaji (Japan)
15:00 – 15:30 Systematic Review of BoNT Treatment
Cynthia Comella (USA)
15:30 – 16:00 Practical Tips for BoNT Treatment
Helio Teive (Brazil)
16:00 – 16:30 Break
16:30-18:00 Selected Oral Presentations
Session Chair: Tony Ward (UK)
16:30-16:45 Muscle Selection For OnabotulinumtoxinA In Poststroke Lower-Limb Spasticity Influences Outcome: Results From a Double-Blind, Placebo-Controlled Phase 3 Clinical Trial
Alberto Esquenazi (USA)
16:45-17:00 Time to Retreatment After AbobotulinumtoxinA (Dysport) Injections in Children With Dynamic Equinus Foot Deformity
Nigar Dursun (Turkey)
17:00-17:15 Safety of OnabotulinumtoxinA Treatment With Concomitant Antithrombotic Therapy In Patients With Post-Stroke Spasticity: A Pooled Analysis of Randomized, Double-Blind Studies
Rozalina Dimitrova (USA)
17:15-17:30 Prospective, Single-Arm, Dose-Titration Study Of IncobotulinumtoxinA (Xeomin; Up To 800 U) For Treatment of Upper- and Lower-Limb Spasticity
Jörg Wissel (Germany)
17:30-17:45 An International, Multicenter, Prospective, Randomized, Evaluator-Blinded Study Comparing Different Botulinum Toxin Injection Strategies For Treatment of Upper Limb Spasticity
Tiina Rekand (Norway)
17:45-18:00 Discussion
Clinical Tracks 2A & 2B – El Escorial Room
14:30 – 16:00 Lifespan Management of Muscle Activity in Cerebral Palsy (CP)
Session Chair: Katharine Alter (USA)
14:30 – 15:00 Management of Pediatric Cerebral Palsy
Florian Heinen (Germany)
15:00 – 15:30 Management of Adolescents/Teens
Sebastian Schröeder (Germany)
15:30 – 16:00 Transition and Management of Adults
Cindy Ivanhoe (USA)
16:00 – 16:30 Break
16:30 – 18:00 Urological Use of BoNT
Session Chair: Michael Chancellor (USA)
16:30 – 17:00 Overactive Bladder Management Strategy and Role of BoNT
Michael Chancellor (USA)
17:00 – 17:30 Emerging Applications of BoNT to Treat Pelvic Pain Syndromes
Christopher Smith (USA)
17:30 – 18:00 Update on BoNT Injections in Multiple Sclerosis and
Interstitial Cystitis/Bladder Pain Syndrome Patients

Francisco Cruz (Portugal)
Clinical Workshops 1A & 1B – Tapices Room
14:30 – 16:00 Cadaver Laboratory
Session Chair: Ellen Gendler (USA)
Discussant: Steven G. Yoelin (USA)
14:30 – 16:00 Prosection of the Face and Neck
Jonathan Sykes (USA)
16:00 – 16:30 Break
16:30-18:00 Cosmetic Uses I
Session Chair:
Ellen Gendler (USA)
16:30 – 17:00 Introduction to the Anatomy of Facial Aesthetics
Jonathan Sykes (USA)
17:00 – 17:30 Evidence-Based Review of BoNT Injections for Aesthetic Use
Doris Hexsel (Brazil)
17:30 – 18:00 A New Botulinum Toxin Type A for the Treatment of Glabellar Lines
Steven G. Yoelin (USA)
Clinical Workshops 2A & 2B – Hospital – Ramon y Cajal
14:30 – 18:00 Hand Dystonia
Session Chair: Mark Hallett (USA)
14:30 – 15:00 Pathophysiology and Therapy Other Than BoNT
Kirsten Zeuner (Germany)
15:00 – 15:30 Review of Clinical Trials
Codrin Lungu (USA)
15:30 – 16:00 Muscle Selection for BoNT
Jennifer Goldman (USA)
16:00 – 16:30 Break
16:30 – 18:00 Hand Dystonia Injection Workshop Demonstrations on Live Patients
Master Injector:
Pedro Garcia-Ruiz (Spain)
Clinical Workshops 3A & 3B – Hospital – Ramon y Cajal
14:30 – 18:00 Hemifacial Spasm and Blepharospasm
Session Chair: Raymond Rosales (Philippines)
14:30 – 15:00 Applying Tailored Assessment Scales in BoNT Injections
Carlo Colosimo (Italy)
15:00 – 15:30 A Review of Evidence of BoNT Treatment
Raymond Rosales (Philippines)
15:30 – 16:00 Practical Tips for BoNT Treatment
Katja Kollewe (Germany)
16:00 – 16:30 Break
16:30 – 18:00 Hemifacial Spasm and Blepharospasm Injection Workshop Demonstrations on Live Patients
Master Injector: Francisco Grandas (Spain)
Clinical Workshops 4A & 4B – Hospital – Ramon y Cajal
14:30 – 18:00 Cervical Dystonia
Session Chair: Buz Jinnah (USA)
14:30 – 15:00 Review of Long-Term Studies and Registries
Buz Jinnah (USA)
15:00 – 15:30 What Are the Obstacles to Optimal Patient Outcomes?
Dirk Dressler (Germany)
15:30 – 16:00 Strategies to Increase Patient-Perceived Benefit
Joseph Tsui (Canada)
16:00 – 16:30 Break
16:30 – 18:00 Cervical Dystonia Injection Workshop Demonstrations on Live Patients
Master Injector:
Juan Carlos Martinez-Castrillo (Spain)
Friday, 20 January, 2017
07:00 – 18:30 Registration / Information
07:00 – 08:30 Exhibits (Patio Areas)
Plenary Session – Auditorium and Castilla
08:30 – 09:00 Evidence on BoNT in Selected Disorders
David Simpson (USA)
09:00 – 09:30 The Booming Number of Novel Botulinum Neurotoxins: A Pandora’s Box of Novel Properties
Eric Johnson (USA)
09:30 – 10:00 Potential New Uses of BoNT Injections in Movement Disorders
Joseph Jankovic (USA)
10:00 – 10:30 Break
10:30 – 11:00 The Binding of BoNT to Different Peripheral Neurons
Ornella Rossetto (Italy)
11:00 – 11:30 Central Effects of BoNT
Matteo Caleo (Italy)
11:30 – 12:00 BoNT for Pain Syndromes
Bahman Jabbari (USA)
12:00 – 13:30 Lunch (Patio Areas)
12:00 – 14:30 Exhibits (Patio Areas)
12:00 – 14:30 Poster Session (Patio Areas)
Participants will break into separate groups for Basic Science, Clinical, Workshops A, and Workshops B.
Parallel Track I (Basic Science) – Auditorium
14:30 – 16:00 Molecular Interactions II
Session Chair: Mauricio Montal (USA)
14:30 – 15:00 Mechanisms of Intestinal Absorption of Botulinum Neurotoxin Complex
Yukako Fujinaga (Japan)
15:00 – 15:15 In Vitro And In Vivo Evaluation Of Syntaxin-Specific BoNT/C
Giulia Zanetti (Italy)
15:15 – 15:30 In Vitro and Ex Vivo Screening of Candidate Therapeutics to Restore Neurotransmission in Nerve Terminals Intoxicated by Botulinum Neurotoxin Serotype A1
Phillip H. Beske (USA)
15:30 – 15:45 HSP90, Thioredoxin And Thioredoxin Reductase Form A Chaperone-Redox Machinery Enabling The Catalytic Activity of Clostridial Neurotoxins Inside Nerve Terminals
Marco Pirazzini (Italy)
15:45 – 16:00 Role of SNARE Proteins in Tumorigenesis and Protein-Engineering SNARE-Inactivating Anti-Cancer Therapeutics
Jianghui Meng (Ireland)
16:00 – 16:30 Break
16:30 – 18:30 Novel BoNTs and Toxin Engineering
Co-Chair: Sabine Pellett (USA)
Co-Chair: Dorothea Sesardic (UK)
16:30 – 17:00 Structural and Functional Insights Into the Interaction of BoNT/A Light Chain With SNAP-25 and SNAP-23
Thomas Binz (Germany)
17:00 – 17:15 Modified rBoNT/A1 Mutants With Accelerated Onset and Shorter Duration of Effect
Daniel Scheps (Germany)
17:15 – 17:30 Engineering Destruction Sites Into Botulinum Neurotoxins
Dina Anderson (UK)
17:30 – 17:45 Light Chain-Modified rBoNT/A1 Mutants With Improved Stability
Manuela López de la Paz (Germany)
17:45 – 18:00 Potency and Duration of Action of BoNT/FA in Cell Models and in Mice
Sabine Pellett (USA)
18:00 – 18:30 Non-Paralytic BoNTs for Pain Control
Bazbek Davletov (UK)
Clinical Tracks 1A & 1B – Castilla Room
14:30-16:00 Selected Oral Presentations
Session Chair: Daniel Truong (USA)
14:30-14:45 High Prevalence of Neutralizing Antibodies In BoNT/A Long-Term–Treated Patients With Focal Dystonia and Spasticity
Harald Hefter (Germany)
14:45-15:00 Real-Life Use of OnabotulinumtoxinA For The Treatment Of Chronic Migraine: 12-Month REPOSE Study Interim Analysis
Julio Pascual (Spain)
15:00-15:15 A Phase 2, Open-Label, Dose-Escalating Study to Evaluate The Safety And Preliminary Efficacy of DaxibotulinumtoxinA For Injection (RT002) In Isolated Cervical Dystonia
Cynthia L. Comella (USA)
15:15-15:30 Clinical Relevance Of Treatment With OnabotulinumtoxinA In Patients With Cervical Dystonia: Results From The CD PROBE Study
Khashayar Dashtipour (USA)
15:30-15:45 MYSTICOL: A Controlled Study Of Myobloc In The Treatment Of Sialorrhea In Parkinson’s Disease (PD) and Other Neurological Conditions
Thomas Clinch (USA)
15:45-16:00 Discussion
Clinical Workshops 1A & 1B – El Escorial Room
14:30 – 18:00 Headache and Pain
Session Chair:
Mark Green (USA)
14:30 – 15:00 Botulinum Toxins for Chronic Migraine: Clinical Trials and Technical Aspects
Cristina Tassorelli (Italy)
15:00 – 15:30 Predictors of Botulinum Toxin Treatment Response in Chronic Migraine
Rami Burstein (USA)
15:30 – 16:00 Botulinum Toxin for Neuropathic Pain
David Simpson (USA)
16:00 – 16:30 Break
16:30 – 18:00 Headache Injection Workshop
Video and Live Patient Demonstrations
Master Injector:
Margarita Sánchez del Río (Spain)
15:45-16:00 Discussion
Clinical Tracks 2A & 2B – Le Jardin
14:30 – 16:00 Spasmodic Dysphonia
Session Chair: Andrew Blitzer (USA)
14:30 – 15:00 Pathology and Treatment Effects in Spasmodic Dysphonia
Enrico Alfonsi (Italy)
15:00 – 15:30 Long-Term Experience With BoNT for Spasmodic Dysphonia
Andrew Blitzer (USA)
15:30 – 16:00 Other Speech and Voice Disorders Treatable with BoNT
Pedro Garcia Ruiz (Spain)
16:00 – 16:30 Break
16:30 – 18:00 Other Neurological Uses
Session Chair: Francisco Cardoso (Brazil)
16:30 – 17:00 BoNT in Parkinsonism: The When, How, and Which for BoNT Injections
Francisco Cardoso (Brazil)
17:00 – 17:30 Tremors: The When, How, and Which for BoNT Injections
Roongroj Bhidayasiri (Thailand)
17:30 – 18:00 Tics: The When, How, and Which for BoNT Injections
Peter Moore (UK)
Clinical Workshops 2A & 2B – Hospital – La Paz
14:30 – 18:00 Cosmetic and Dermatologic Uses II
Session Chair: Ellen Gendler (USA)
14:30 – 15:00 Aesthetic BoNT Injections of the Face: Options and Outcomes
Ellen Gendler (USA)
15:00 – 15:30 Beyond Rhytids: Facial Contouring With Botulinum Toxin
Steven G. Yoelin (USA)
15:30 – 16:00 BoNT Injections for Hyperhidrosis: Technical Pearls
Dee Anna Glaser (USA)
16:00 – 16:30 Break
16:30 – 18:00 Cosmetic and Dermatologic Uses II Injection Workshop
Demonstrations on Live Patients

Master Injector: Juan Sopena (Spain)
Clinical Workshop 3A & 3B – Hospital – La Paz
14:30 – 18:00 Spasticity
Session Chair: Allison Brashear (USA)
Discussant: Tony Ward (United Kingdom)
14:30 – 15:00 Pathophysiology, Assessment, and Treatment of Spastic Paresis
Jean-Michel Gracies (France)
15:00 – 15:30 Botulinum Toxin in the Treatment of Upper Extremity Spasticity
Allison Brashear (USA)
15:30 – 16:00 Botulinum Toxin in the Treatment of Lower Extremity Spasticity
Alberto Esquenazi (USA)
16:00 – 16:30 Break
16:30 – 18:00 Spasticity Injection Workshop, Demonstrations on Live Patients
Master Injectors:
Susana Moraleda & Mercedes Martínez-Moreno (Spain)
Clinical Workshops 4A & 4B – Hospital – La Paz
14:30 – 18:00 Techniques for Localizing Muscles for BoNT Injections
Session Chair: Marina de Koning-Tijssen (The Netherlands)
14:30 – 15:00 EMG/Guidance and Polymyograpy
Marina de Koning-Tijssen (The Netherlands)
15:00 – 15:30 Ultrasound
Katharine Alter (USA)
15:30 – 16:00 Other Techniques
Erle Lim (Singapore)
16:00 – 16:30 Break
16:30 – 18:00 Lifespan Management of Muscle Activity in Cerebral Palsy Injection Workshop, Demonstrations on Live Patients
Master Injector: Samuel Ignacio Pascual-Pascual (Spain)
Saturday, January 21, 2017
07:00 – 18:30 Registration / Information
07:00 – 08:30 Exhibits
Plenary Session – Auditorium and Castilla
07:45-08:30 INA Members Business Meeting
08:30 – 08:45 Awards
Joseph Jankovic (USA) & Alberto Albanese (Italy)
08:45 – 09:00 A Weissella oryzae Botulinum-Like Toxin Cleaves VAMP Within The Juxtamembrane Domain
Cesare Montecucco (Italy)
09:00 – 09:20 Controversy – PRO
BoNT for Headache:
PREEMPT vs. Individualized Treatment
John Rothrock (USA)
09:20 – 09:40 Controversy – CON
BoNT for Headache:
PREEMPT vs. Individualized Treatment
Mark Green (USA)
09:40 – 10:20 TeNT Uptake and Transport
Giampietro Schiavo (UK)
10:20 – 10:30 Closing Remarks
Giampietro Schiavo (UK)
10:30 – 11:00 Break
Parallel Track I (Basic Science) – Auditorium
11:00 – 13:00 Detection and Protection
Session Chair: Markus Kalkum (USA)
11:00 – 11:30 CMAP for Quantitative Detection of BoNTs
Yasushi Torii (Japan)
11:30 – 11:45 Engineered Luciferase Pro-Enzymes for the Bioluminescent Detection of Botulinum Neurotoxins
Markus Kalkum (USA)
11:45 – 12:00 Development of the BINACLE (Binding and Cleavage) Assay for the In Vitro Potency Testing of Botulinum Neurotoxins
Heike Behrensdorf-Nicol (Germany)
12:00 – 12:30 Endopep-MS and Hc-Based Neutralizing Oligoclonal Antibody Mixture
Ran Zichel (Israel)
12:30 – 13:00 Outcome of the ANTIBOTABE mAB Development Project
Michael Hust (Germany)