Download TOXINS 2017 Program Schedule at a Glance
| Wednesday, 18 January, 2017 | |
| All Day | Exhibit Setup |
| 10:00 – 18:00 | Registration Open |
| 10:00 – 18:00 | Poster Setup |
| Auditorium and Castilla | |
| 18:00 – 18:30 | Welcome and Opening Remarks and Lifetime Achievement Award Ceremony Joseph Jankovic (USA) Alberto Albanese (Italy) |
| 18:30-19:00 | Unexpected Consequences Mark Hallett (USA) |
| 19:00 – 19:30 | DasGupta Memorial Lecture: Cesare Montecucco (Italy) |
| 19:30 – 22:00 | Welcome Reception – Tapices Room |
| Thursday, 19 January, 2017 | |
| 07:00 – 18:30 | Registration / Information |
| 07:00 – 08:30 | Exhibits (Patio Areas) |
| Plenary Session – Auditorium and Castilla |
|
| 08:30 – 08:40 | Welcome and Opening Remarks and Introduction of Keynote Speaker Andreas Rummel (Germany) |
| 08:40 – 09:30 | Keynote Presentation – Presynaptic Functions Erik M. Jorgensen (USA) |
| 09:30 – 10:00 | Assembly and Disassembly of the SNARE Complex Axel Brunger (USA) |
| 10:00 – 10:30 | What’s the Best Dosage and Interval for BoNT Injections in Dystonia and Spasticity Treatment? Jörg Wissel (Germany) |
| 10:30 – 11:00 | Break |
| 11:00 – 11:30 | Recent Developments in Clinical Trials of BoNT Alberto Albanese (Italy) |
| 11:30 – 12:00 | Advances in the Architecture of the BoNT Complex Rongsheng Jin (USA) |
| 12:00 – 13:30 | Lunch (Patio Areas) |
| 12:00 – 14:30 | Exhibits (Patio Areas) |
| 12:00 – 14:30 | Poster Session (Patio Areas) |
| Participants will break into separate groups for Basic Science, Clinical, Workshops A, and Workshops B. | |
| Parallel Track I (Basic Science) Auditorium |
|
| 14:30 – 16:00 | Genetics and Evolution Session Chair: Cesare Montecucco (Italy) |
| 14:30 – 15:00 | Regulation of C. Botulinum Growth and Toxin Production Miia Lindström (Finland) |
| 15:00 – 15:30 | Botulinum Neurotoxin Homologs in Non-Clostridial Species Andrew Doxey (Canada) |
| 15:30 – 15:45 | Identification And Characterization Of A Novel Botulinum Neurotoxin Pål Stenmark (Sweden) |
| 15:45 – 16:00 | A Functional Assay Devoid of Antibodies For Serotyping and Detection of Botulinum Neurotoxins Jasmin Weisemann (Germany) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:30 | Molecular Interactions I Session Chair: Giampietro Schiavo (UK) |
| 16:30 – 17:00 | Binding of BoNT to Glycosylated SV2 Stefan Mahrhold (Germany) |
| 17:00 – 17:30 | Botulinum Neurotoxin Type A Enters a Non-Recycling Pool of Synaptic Vesicles Frederic Meunier (Australia) |
| 17:30 – 18:00 | Botulinum Neurotoxins Inhibit Cytokine-Induced Trafficking of TRPV1 and A1 in Cultured Sensory Neurons Oliver Dolly (Ireland) |
| 18:00 – 18:30 | Translocation and Dissemination to Target Neurons of Botulinum Neurotoxin Type B in the Mouse Intestinal Wall Michel R. Popoff (France) |
| Clinical Tracks 1A & 1B – Castilla Room |
|
| 14:30 – 16:00 | Oromandibular Dystonia Session Chair: Cynthia Comella (USA) |
| 14:30 – 15:00 | Pathophysiology and Clinical Features Ryuji Kaji (Japan) |
| 15:00 – 15:30 | Systematic Review of BoNT Treatment Cynthia Comella (USA) |
| 15:30 – 16:00 | Practical Tips for BoNT Treatment Helio Teive (Brazil) |
| 16:00 – 16:30 | Break |
| 16:30-18:00 | Selected Oral Presentations Session Chair: Tony Ward (UK) |
| 16:30-16:45 | Muscle Selection For OnabotulinumtoxinA In Poststroke Lower-Limb Spasticity Influences Outcome: Results From a Double-Blind, Placebo-Controlled Phase 3 Clinical Trial Alberto Esquenazi (USA) |
| 16:45-17:00 | Time to Retreatment After AbobotulinumtoxinA (Dysport) Injections in Children With Dynamic Equinus Foot Deformity Nigar Dursun (Turkey) |
| 17:00-17:15 | Safety of OnabotulinumtoxinA Treatment With Concomitant Antithrombotic Therapy In Patients With Post-Stroke Spasticity: A Pooled Analysis of Randomized, Double-Blind Studies Rozalina Dimitrova (USA) |
| 17:15-17:30 | Prospective, Single-Arm, Dose-Titration Study Of IncobotulinumtoxinA (Xeomin; Up To 800 U) For Treatment of Upper- and Lower-Limb Spasticity Jörg Wissel (Germany) |
| 17:30-17:45 | An International, Multicenter, Prospective, Randomized, Evaluator-Blinded Study Comparing Different Botulinum Toxin Injection Strategies For Treatment of Upper Limb Spasticity Tiina Rekand (Norway) |
| 17:45-18:00 | Discussion |
| Clinical Tracks 2A & 2B – El Escorial Room |
|
| 14:30 – 16:00 | Lifespan Management of Muscle Activity in Cerebral Palsy (CP) Session Chair: Katharine Alter (USA) |
| 14:30 – 15:00 | Management of Pediatric Cerebral Palsy Florian Heinen (Germany) |
| 15:00 – 15:30 | Management of Adolescents/Teens Sebastian Schröeder (Germany) |
| 15:30 – 16:00 | Transition and Management of Adults Cindy Ivanhoe (USA) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:00 | Urological Use of BoNT Session Chair: Michael Chancellor (USA) |
| 16:30 – 17:00 | Overactive Bladder Management Strategy and Role of BoNT Michael Chancellor (USA) |
| 17:00 – 17:30 | Emerging Applications of BoNT to Treat Pelvic Pain Syndromes Christopher Smith (USA) |
| 17:30 – 18:00 | Update on BoNT Injections in Multiple Sclerosis and Interstitial Cystitis/Bladder Pain Syndrome Patients Francisco Cruz (Portugal) |
| Clinical Workshops 1A & 1B – Tapices Room |
|
| 14:30 – 16:00 | Cadaver Laboratory Session Chair: Ellen Gendler (USA) Discussant: Steven G. Yoelin (USA) |
| 14:30 – 16:00 | Prosection of the Face and Neck Jonathan Sykes (USA) |
| 16:00 – 16:30 | Break |
| 16:30-18:00 | Cosmetic Uses I Session Chair: Ellen Gendler (USA) |
| 16:30 – 17:00 | Introduction to the Anatomy of Facial Aesthetics Jonathan Sykes (USA) |
| 17:00 – 17:30 | Evidence-Based Review of BoNT Injections for Aesthetic Use Doris Hexsel (Brazil) |
| 17:30 – 18:00 | A New Botulinum Toxin Type A for the Treatment of Glabellar Lines Steven G. Yoelin (USA) |
| Clinical Workshops 2A & 2B – Hospital – Ramon y Cajal |
|
| 14:30 – 18:00 | Hand Dystonia Session Chair: Mark Hallett (USA) |
| 14:30 – 15:00 | Pathophysiology and Therapy Other Than BoNT Kirsten Zeuner (Germany) |
| 15:00 – 15:30 | Review of Clinical Trials Codrin Lungu (USA) |
| 15:30 – 16:00 | Muscle Selection for BoNT Jennifer Goldman (USA) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:00 | Hand Dystonia Injection Workshop Demonstrations on Live Patients Master Injector: Pedro Garcia-Ruiz (Spain) |
| Clinical Workshops 3A & 3B – Hospital – Ramon y Cajal |
|
| 14:30 – 18:00 | Hemifacial Spasm and Blepharospasm Session Chair: Raymond Rosales (Philippines) |
| 14:30 – 15:00 | Applying Tailored Assessment Scales in BoNT Injections Carlo Colosimo (Italy) |
| 15:00 – 15:30 | A Review of Evidence of BoNT Treatment Raymond Rosales (Philippines) |
| 15:30 – 16:00 | Practical Tips for BoNT Treatment Katja Kollewe (Germany) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:00 | Hemifacial Spasm and Blepharospasm Injection Workshop Demonstrations on Live Patients Master Injector: Francisco Grandas (Spain) |
| Clinical Workshops 4A & 4B – Hospital – Ramon y Cajal |
|
| 14:30 – 18:00 | Cervical Dystonia Session Chair: Buz Jinnah (USA) |
| 14:30 – 15:00 | Review of Long-Term Studies and Registries Buz Jinnah (USA) |
| 15:00 – 15:30 | What Are the Obstacles to Optimal Patient Outcomes? Dirk Dressler (Germany) |
| 15:30 – 16:00 | Strategies to Increase Patient-Perceived Benefit Joseph Tsui (Canada) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:00 | Cervical Dystonia Injection Workshop Demonstrations on Live Patients Master Injector: Juan Carlos Martinez-Castrillo (Spain) |
| Friday, 20 January, 2017 | |
| 07:00 – 18:30 | Registration / Information |
| 07:00 – 08:30 | Exhibits (Patio Areas) |
| Plenary Session – Auditorium and Castilla |
|
| 08:30 – 09:00 | Evidence on BoNT in Selected Disorders David Simpson (USA) |
| 09:00 – 09:30 | The Booming Number of Novel Botulinum Neurotoxins: A Pandora’s Box of Novel Properties Eric Johnson (USA) |
| 09:30 – 10:00 | Potential New Uses of BoNT Injections in Movement Disorders Joseph Jankovic (USA) |
| 10:00 – 10:30 | Break |
| 10:30 – 11:00 | The Binding of BoNT to Different Peripheral Neurons Ornella Rossetto (Italy) |
| 11:00 – 11:30 | Central Effects of BoNT Matteo Caleo (Italy) |
| 11:30 – 12:00 | BoNT for Pain Syndromes Bahman Jabbari (USA) |
| 12:00 – 13:30 | Lunch (Patio Areas) |
| 12:00 – 14:30 | Exhibits (Patio Areas) |
| 12:00 – 14:30 | Poster Session (Patio Areas) |
| Participants will break into separate groups for Basic Science, Clinical, Workshops A, and Workshops B. | |
| Parallel Track I (Basic Science) – Auditorium |
|
| 14:30 – 16:00 | Molecular Interactions II Session Chair: Mauricio Montal (USA) |
| 14:30 – 15:00 | Mechanisms of Intestinal Absorption of Botulinum Neurotoxin Complex Yukako Fujinaga (Japan) |
| 15:00 – 15:15 | In Vitro And In Vivo Evaluation Of Syntaxin-Specific BoNT/C Giulia Zanetti (Italy) |
| 15:15 – 15:30 | In Vitro and Ex Vivo Screening of Candidate Therapeutics to Restore Neurotransmission in Nerve Terminals Intoxicated by Botulinum Neurotoxin Serotype A1 Phillip H. Beske (USA) |
| 15:30 – 15:45 | HSP90, Thioredoxin And Thioredoxin Reductase Form A Chaperone-Redox Machinery Enabling The Catalytic Activity of Clostridial Neurotoxins Inside Nerve Terminals Marco Pirazzini (Italy) |
| 15:45 – 16:00 | Role of SNARE Proteins in Tumorigenesis and Protein-Engineering SNARE-Inactivating Anti-Cancer Therapeutics Jianghui Meng (Ireland) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:30 | Novel BoNTs and Toxin Engineering Co-Chair: Sabine Pellett (USA) Co-Chair: Dorothea Sesardic (UK) |
| 16:30 – 17:00 | Structural and Functional Insights Into the Interaction of BoNT/A Light Chain With SNAP-25 and SNAP-23 Thomas Binz (Germany) |
| 17:00 – 17:15 | Modified rBoNT/A1 Mutants With Accelerated Onset and Shorter Duration of Effect Daniel Scheps (Germany) |
| 17:15 – 17:30 | Engineering Destruction Sites Into Botulinum Neurotoxins Dina Anderson (UK) |
| 17:30 – 17:45 | Light Chain-Modified rBoNT/A1 Mutants With Improved Stability Manuela López de la Paz (Germany) |
| 17:45 – 18:00 | Potency and Duration of Action of BoNT/FA in Cell Models and in Mice Sabine Pellett (USA) |
| 18:00 – 18:30 | Non-Paralytic BoNTs for Pain Control Bazbek Davletov (UK) |
| Clinical Tracks 1A & 1B – Castilla Room |
|
| 14:30-16:00 | Selected Oral Presentations Session Chair: Daniel Truong (USA) |
| 14:30-14:45 | High Prevalence of Neutralizing Antibodies In BoNT/A Long-Term–Treated Patients With Focal Dystonia and Spasticity Harald Hefter (Germany) |
| 14:45-15:00 | Real-Life Use of OnabotulinumtoxinA For The Treatment Of Chronic Migraine: 12-Month REPOSE Study Interim Analysis Julio Pascual (Spain) |
| 15:00-15:15 | A Phase 2, Open-Label, Dose-Escalating Study to Evaluate The Safety And Preliminary Efficacy of DaxibotulinumtoxinA For Injection (RT002) In Isolated Cervical Dystonia Cynthia L. Comella (USA) |
| 15:15-15:30 | Clinical Relevance Of Treatment With OnabotulinumtoxinA In Patients With Cervical Dystonia: Results From The CD PROBE Study Khashayar Dashtipour (USA) |
| 15:30-15:45 | MYSTICOL: A Controlled Study Of Myobloc In The Treatment Of Sialorrhea In Parkinson’s Disease (PD) and Other Neurological Conditions Thomas Clinch (USA) |
| 15:45-16:00 | Discussion |
| Clinical Workshops 1A & 1B – El Escorial Room |
|
| 14:30 – 18:00 | Headache and Pain Session Chair: Mark Green (USA) |
| 14:30 – 15:00 | Botulinum Toxins for Chronic Migraine: Clinical Trials and Technical Aspects Cristina Tassorelli (Italy) |
| 15:00 – 15:30 | Predictors of Botulinum Toxin Treatment Response in Chronic Migraine Rami Burstein (USA) |
| 15:30 – 16:00 | Botulinum Toxin for Neuropathic Pain David Simpson (USA) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:00 | Headache Injection Workshop Video and Live Patient Demonstrations Master Injector: Margarita Sánchez del Río (Spain) |
| 15:45-16:00 | Discussion |
| Clinical Tracks 2A & 2B – Le Jardin |
|
| 14:30 – 16:00 | Spasmodic Dysphonia Session Chair: Andrew Blitzer (USA) |
| 14:30 – 15:00 | Pathology and Treatment Effects in Spasmodic Dysphonia Enrico Alfonsi (Italy) |
| 15:00 – 15:30 | Long-Term Experience With BoNT for Spasmodic Dysphonia Andrew Blitzer (USA) |
| 15:30 – 16:00 | Other Speech and Voice Disorders Treatable with BoNT Pedro Garcia Ruiz (Spain) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:00 | Other Neurological Uses Session Chair: Francisco Cardoso (Brazil) |
| 16:30 – 17:00 | BoNT in Parkinsonism: The When, How, and Which for BoNT Injections Francisco Cardoso (Brazil) |
| 17:00 – 17:30 | Tremors: The When, How, and Which for BoNT Injections Roongroj Bhidayasiri (Thailand) |
| 17:30 – 18:00 | Tics: The When, How, and Which for BoNT Injections Peter Moore (UK) |
| Clinical Workshops 2A & 2B – Hospital – La Paz |
|
| 14:30 – 18:00 | Cosmetic and Dermatologic Uses II Session Chair: Ellen Gendler (USA) |
| 14:30 – 15:00 | Aesthetic BoNT Injections of the Face: Options and Outcomes Ellen Gendler (USA) |
| 15:00 – 15:30 | Beyond Rhytids: Facial Contouring With Botulinum Toxin Steven G. Yoelin (USA) |
| 15:30 – 16:00 | BoNT Injections for Hyperhidrosis: Technical Pearls Dee Anna Glaser (USA) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:00 | Cosmetic and Dermatologic Uses II Injection Workshop Demonstrations on Live Patients Master Injector: Juan Sopena (Spain) |
| Clinical Workshop 3A & 3B – Hospital – La Paz |
|
| 14:30 – 18:00 | Spasticity Session Chair: Allison Brashear (USA) Discussant: Tony Ward (United Kingdom) |
| 14:30 – 15:00 | Pathophysiology, Assessment, and Treatment of Spastic Paresis Jean-Michel Gracies (France) |
| 15:00 – 15:30 | Botulinum Toxin in the Treatment of Upper Extremity Spasticity Allison Brashear (USA) |
| 15:30 – 16:00 | Botulinum Toxin in the Treatment of Lower Extremity Spasticity Alberto Esquenazi (USA) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:00 | Spasticity Injection Workshop, Demonstrations on Live Patients Master Injectors: Susana Moraleda & Mercedes Martínez-Moreno (Spain) |
| Clinical Workshops 4A & 4B – Hospital – La Paz |
|
| 14:30 – 18:00 | Techniques for Localizing Muscles for BoNT Injections Session Chair: Marina de Koning-Tijssen (The Netherlands) |
| 14:30 – 15:00 | EMG/Guidance and Polymyograpy Marina de Koning-Tijssen (The Netherlands) |
| 15:00 – 15:30 | Ultrasound Katharine Alter (USA) |
| 15:30 – 16:00 | Other Techniques Erle Lim (Singapore) |
| 16:00 – 16:30 | Break |
| 16:30 – 18:00 | Lifespan Management of Muscle Activity in Cerebral Palsy Injection Workshop, Demonstrations on Live Patients Master Injector: Samuel Ignacio Pascual-Pascual (Spain) |
| Saturday, January 21, 2017 | |
| 07:00 – 18:30 | Registration / Information |
| 07:00 – 08:30 | Exhibits |
| Plenary Session – Auditorium and Castilla |
|
| 07:45-08:30 | INA Members Business Meeting |
| 08:30 – 08:45 | Awards Joseph Jankovic (USA) & Alberto Albanese (Italy) |
| 08:45 – 09:00 | A Weissella oryzae Botulinum-Like Toxin Cleaves VAMP Within The Juxtamembrane Domain Cesare Montecucco (Italy) |
| 09:00 – 09:20 | Controversy – PRO BoNT for Headache: PREEMPT vs. Individualized Treatment John Rothrock (USA) |
| 09:20 – 09:40 | Controversy – CON BoNT for Headache: PREEMPT vs. Individualized Treatment Mark Green (USA) |
| 09:40 – 10:20 | TeNT Uptake and Transport Giampietro Schiavo (UK) |
| 10:20 – 10:30 | Closing Remarks Giampietro Schiavo (UK) |
| 10:30 – 11:00 | Break |
| Parallel Track I (Basic Science) – Auditorium |
|
| 11:00 – 13:00 | Detection and Protection Session Chair: Markus Kalkum (USA) |
| 11:00 – 11:30 | CMAP for Quantitative Detection of BoNTs Yasushi Torii (Japan) |
| 11:30 – 11:45 | Engineered Luciferase Pro-Enzymes for the Bioluminescent Detection of Botulinum Neurotoxins Markus Kalkum (USA) |
| 11:45 – 12:00 | Development of the BINACLE (Binding and Cleavage) Assay for the In Vitro Potency Testing of Botulinum Neurotoxins Heike Behrensdorf-Nicol (Germany) |
| 12:00 – 12:30 | Endopep-MS and Hc-Based Neutralizing Oligoclonal Antibody Mixture Ran Zichel (Israel) |
| 12:30 – 13:00 | Outcome of the ANTIBOTABE mAB Development Project Michael Hust (Germany) |