Abstract Committee Review

This is a well-written and clinically relevant abstract addressing long-term dosing trends of abobotulinumtoxinA in hemifacial spasm. The topic is of clear interest to the neurotoxin community, and the findings are consistent with reports in other indications where gradual dose escalation is observed over extended treatment periods. The study benefits from a relatively large cohort with long follow-up, which strengthens its conclusions. The presentation following this abstract would benefit from additional clarification on whether the observed dose increase reflects secondary non-responsiveness, disease progression, or other treatment-related factors. Furthermore, the clinical impact of the reported dosing trends on efficacy and safety is not fully explored. Overall, this work provides useful data that contribute to understanding long-term treatment dynamics in hemifacial spasm.