TOXINS 2022 Conference Program

Wednesday, January 12, 2022
8:00 am – 5:00 pm Poster Hall Setup
9:00 am – 8:30 pm Registration Opens
6:00 pm – 8:00 pm Welcome Reception
Poster Hall Open

Thursday, January 13, 2022
7:30 am – 6:30 pm Registration/Information
7:30 am – 8:30 am Breakfast
Poster Hall Open
8:30 am – 12:00 noon Plenary Session
8:30 am – 8:45 am Opening Session
8:45 am – 9:30 am Physiologic Considerations for Novel BoNT–Based Therapeutics and Indications (Improving BoNT Targeting)
Keynote Speaker: Min Dong, PhD
9:30 am – 10:00 am Focus on BoNT Engineering (Phage–Assisted Evolution of Botulinum Neurotoxin Proteases with Reprogrammed Specificity)
Travis Blum, PhD
10:00 am – 10:30 am Basis of Movement Control and Why Botulinum Toxin Should Influence It
Aparna Wagle Shukla, MD
10:30 am – 11:00 am Break
Poster Hall Open
11:00 am – 12:00 noon Botulinum Toxin in the COVID Era: Issues and Challenges
Chris Boulias, MD, PhD
Barbara Karp, MD
David Simpson, MD
12:00 noon – 2:00 pm Break
Poster Hall Open

Time Basic Science Track Time Clinical Track 1A Time Clinical Track 2A Time Clinical Track 3A
2:00 pm – 3:35 pm History, Genetics, and Evolution 2:00 pm – 3:35 pm Spasticity 2:00 pm – 3:35 pm Cervical Dystonia & Focal Limb Dystonia 2:00 pm – 3:35 pm Aesthetic Medicine and Dermatology
2:00 pm – 2:25 pm The First FDA Approved Batches of Pharmaceutical Botulinum Toxin
Eric Johnson, ScD
2:00 pm – 2:25 pm What's New? BoNT Clinical Trial Update: Adult Spasticity
Gerard Francisco, MD
2:00 pm – 2:20 pm What's New? BoNT Clinical Trial Update: Cervical Dystonia
Cindy Comella, MD
2:00 pm – 2:35 pm Essential Anatomy and Injection Technique: Neuromodulators for Aesthetic Use in the Upper, Mid and Lower Face
Steven Yoelin, MD
Wendy Lee, MD
2:25 pm – 2:50 pm Geographical Distribution of C. botulinum Phyla
Carolina Luquez, PhD
2:25 pm – 2:45 pm Gait Pattern Recognition and Muscle Selection for BoNT Injections
Alberto Esquenazi, MD
2:20 pm – 2:40 pm Anatomy and Ultrasound-Guided Injection of Deep Neck Muscles for Anterocollis
Katharine Alter, MD
2:35 pm – 2:55 pm Clinical Implications of the Long-Term Use of Neuromodulators for Aesthetic Indications
Michael Kane, MD
2:50 pm – 3:15 pm Chromosomally Integrated Plasmids in G1 C. botulinum
Kristin Schill, PhD
2:45 pm – 3:05 pm What Are We Missing? It’s More Than Injections
Laura Wiggs, PT, NCS, CBIS
2:40 pm – 3:00 pm Focal Limb Dystonia and Tremor: A Look at the BoNT Data
2:55 pm - 3:10 pm Panel Discussion
Michael Kane, MD
Wendy Lee, MD
Nowell Solish, MD
Steven Yoelin, MD
3:15 pm – 3:35 pm 2 Selected Abstracts
3:05 pm - 3:20 pm Balancing Dosing in Patients Who Need More Than You Can Give
Cindy Ivanhoe, MD
3:00 pm - 3:20 pm Focal Limb Dystonia: Focus on Injection Technique
David Simpson, MD
3:10 pm - 3:35 pm 2 Selected Abstracts

3:20 pm – 3:35 pm 2 Selected Abstracts

3:20 pm – 3:35 pm 2 Selected Abstracts

3:35 pm – 3:55 pm Break
Poster Hall Open
3:35 pm – 3:55 pm Break
Poster Hall Open
3:35 pm – 3:55 pm Break
Poster Hall Open
3:35 pm – 3:55 pm Break
Poster Hall Open
Time Basic Science Track Time Clinical Track 1B Time Clinical Track 2B Time Clinical Track 3B Time Injection Demonstration Workshop
3:55 pm – 5:30 pm Toxin Engineering and Pharmacokinetics


3:55 pm – 5:30 pm Oromandibular Dystonia (OMD), Spasmodic Dysphonia, Blepharospasm, and Meige Syndrome 3:55 pm – 5:25 pm Practical Considerations
3:55 pm – 5:30 pm Selected Topics I 3:55 pm – 5:30 pm Aesthetic Medicine and Dermatology: Round Robin Injection Workshop
3:55 pm – 4:20 pm Botulinum Neurotoxin Trafficking Within Motor Neurons
Patrick M. McNutt, PhD
3:55 pm – 4:15 pm Clinical Features of OMD: A Summary of More Than 2000 Cases
H. A. Jinnah, MD
3:55 pm – 4:25 pm Clinical Aspects Associated With BoNT Properties: Does Altering the Onset of Action and Increasing Duration of Action Really Matter in Clinical Practice?
Mark Hallett, MD
3:55 pm – 4:20 pm Applications of Botulinum Toxin: The Female Pelvic Floor
Barbara Karp, MD
3:55 pm – 5:30 pm Deidera O'Boyle Hooper, MD
4:20 pm – 4:45 pm Spectroscopic Insights Into the Translocation Domain: Membrane Insertion and Refolding of Tetanus Toxin/Cellular Entry of Binary and Pore-Forming Bacterial Toxins
4:15 pm – 4:35 pm What's New? BoNT Clinical Trial Update: OMD
Nikita Kohli, MD
4:25 pm – 4:55 pm Dosing Intervals With BoNT: Managing Multiple Indications and Boosters
David Simpson, MD
4:20 pm – 4:45 pm Botulinum Toxin in Parkinsonian Disorders
Robert Chen, MD
4:45 pm – 5:10 pm Engineering BoNTs as Vehicles for Drug Delivery/ Neuronal Delivery Vehicles Using Antibodies for BoNT Intoxication
Konstantin Ichtchenko, PhD
4:35 pm – 4:55 pm Spasmodic Dysphonia
Andrew Blitzer, MD
4:45 pm – 5:10 pm Effects of Toxin Non-Motor Symptoms in Dystonia
H. A. Jinnah, MD
5:10 pm – 5:30 pm 2 Selected Abstracts

4:55 pm – 5:20 pm How to Adjust Expectations and Manage a Newly-Diagnosed Blepharospasm and Meige Syndrome Patient
Barbara Karp, MD
4:55 pm - 5:25 pm 3 Selected Abstracts 5:10 pm – 5:30 pm 2 Selected Abstracts
5:20 pm – 5:30 pm 2 Selected Abstracts

Friday, January 14, 2022
8:00 am – 6:30 pm Registration/Information
7:30 am – 8:30 am Breakfast
Poster Hall Open
8:30 am – 12:00 noon Plenary Session
8:30 am – 9:00 am BoNT as a Treatment Option for Age-Related Macular Degeneration (AMD)
9:00 am – 9:30 am BoNT in the Management of Neuropathic Pain
Nadine Attal, MD, PhD (France)
9:30 am – 10:00 am The Emerging Role of Botulinum Toxin in Cardiology
Jonathan S. Steinberg, MD
10:00 am – 10:30 am Wound Healing
10:30 am – 11:00 am Break
Poster Hall Open
11:00 am – 12:00 noon Depression Roundtable: Is there a role for BoNT in the Management of Depression?
Moderator: Mark Hallett, MD
T.H.C. Krüger, PhD (Germany)
Nicholas A. Coles, PhD
Ornella Rossetto, PhD (Italy)
12:00 noon – 2:00 pm Lunch
Poster Hall Open

Time Basic Science Track Time Injection Demonstration Workshop 1A Time Clinical Track 1A Time Clinical Track 2A
2:00 pm – 3:35 pm Structural and Functional Aspects of BoNTs 2:00 pm – 3:35 pm Pediatric Spasticity
2:00 pm – 3:35 pm Headache and Pain
2:00 pm – 3:35 pm Aesthetic Medicine and Dermatology
2:00 pm – 2:25 pm Are Non-Clostridial Homologs Botulinum Neurotoxins?
Travis Wentz, PhD
2:00 pm – 2:30 pm Results of Upper and Lower Limb Management of Cerebral Palsy: Are There any Differences Related to the Toxin or Injection Technique Used?
Katharine Alter, MD
2:00 pm – 2:30 pm BoNT for Suppression of Chronic Migraine: What Have We Learned in 10+ Years?
John Rothrock, MD
2:00 pm – 2:35 pm Update on Hyperhidrosis
Dee Anna Glaser, MD
2:25 pm – 2:50 pm Novel Structure-Function Aspects of Clostridial Neurotoxins, Function Emphasis
Andreas Rummel, PhD (Germany)
2:30 pm – 3:35 pm Therapeutic Use of BoNT Injection Demonstration Workshop

Pediatric Spasticity
Ann Tilton, MD
2:30 pm – 2:50 pm BoNT, mAbs, and Gepants: Elegant Synergism or Expensive Redundancy?
2:50 pm – 3:15 pm Tetanus Toxin cis-Loop Contributes to Light-Chain Translocation
Joseph Barbier, PhD
2:50 pm – 3:05 pm Use of BoNT in Treating Persistent Post-Traumatic Headache
John Rothrock, MD
2:35 pm – 3:15 pm Micro Toxin Technique: What, Why and Where?
Woffles Wu, FRCS, FAMS
3:15 pm – 3:35 pm 2 Selected Abstracts
3:05 pm – 3:35 pm 3 Selected Abstracts


3:15 pm - 3:35 pm 2 Selected Abstracts

3:35 pm - 3:55 pm Break
Poster Hall Open
3:35 pm - 3:55 pm Break
Poster Hall Open
3:35 pm - 3:55 pm Break
Poster Hall Open
3:35 pm - 3:55 pm Break
Poster Hall Open
Time Basic Science Track Time Injection Demonstration Workshop 1B Time Clinical Track 1B Time Clinical Track 2B
3:55 pm – 5:30 pm BoNT Detection and Countermeasures


3:55 pm – 5:30 pm Cervical Dystonia, Adult Spasticity, and Focal Limb Dystonia
3:55 pm – 5:30 pm Selected Topics II 3:55 pm – 5:30 pm Aesthetic Medicine and Dermatology
3:55 pm – 4:20 pm Detection of Select Agent Toxins in Support of Public Health Activities
Suzy Kalb, PhD
3:55 pm – 4:25 pm Cervical Dystonia
3:55 pm – 4:20 pm Clinical Update: The Use of BoNT in the Bladder
Roger Dmochowski, MD
3:55 pm – 4:30 pm The Use of Neuromodulators for Facial Shaping
Woffles Wu, FRCS, FAMS
4:20 pm – 4:45 pm Peptide Inhibitors of BoNT/A
Nick Salzamed, PhD
4:25 pm – 5:00 pm Adult Spasticity
Shivani Gupta, MD
4:20 pm – 4:45 pm Changes in Cortical Excitability and Plasticity After Botulinum Toxin Injecton
Robert Chen, MD
4:30 pm – 5:10 pm Neuromodulators From Around the World: What’s Here and What’s to Come
Nowell Solish, MD
4:45 pm – 5:10 pm Monoclonal Antibody Combinations for the Prevention and Treatment of Botulism
Jim Marks, PhD
4:45 pm – 5:10 pm Functional or Psychogenic Dystonia: Should We Inject BoNT?
5:10 pm – 5:30 pm 2 Selected Abstracts

5:10 pm – 5:30 pm 2 Selected Abstracts 5:00 pm – 5:35 pm Focal Limb Dystonia 5:10 pm - 5:25 pm 2 Selected Abstracts

Saturday, January 15, 2022
7:30 am – 12:00 noon Information
8:00 am – 9:00 am Breakfast
Poster Hall Open
9:00 am – 11:30 am Plenary Session
9:00 am – 9:45 am Questions About BoNT You Were Afraid to Ask
9:45 am – 10:15 am A Look at the Future―New BoNTs and Delivery Systems in Development: A View From the Bench
Sabine Pellett, PhD
10:15 am – 10:45 am A Look at the Future―New BoNTs and Delivery Systems in Development: What it Could Mean in the Clinic
10:45 am – 11:05 am Best Clinical Abstract
11:05 am – 11:25 am Best Basic Science Abstract
11:25 am – 11:30 am Closing
Cindy Comella, MD