| Wednesday, 13 January, 2021 | |
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| All Day | Exhibit Setup |
| 10:00 – 19:00 | Registration Open |
| 10:00 – 19:00 | Poster Setup |
| 12:00 – 16:00 | TOXINS 101 Preconference Workshop Learn more |
| 18:00 – 19:30 | Opening Session Chair: Giampietro Schiavo (UK) |
| 18:00 – 18:30 | Welcome and Opening Remarks and Lifetime Achievement Awards Ceremony Co-chairs: Giampietro Schiavo (UK) Mark Hallett (USA) |
| 18:30 – 19:00 | Presentation by Basic Science Lifetime Achievement Award Recipient Cesare Montecucco (Italy) |
| 19:00 – 19:30 | Presentation by Clinical Lifetime Achievement Award Recipient Joseph Jankovic (USA) |
| 19:30 – 22:00 | Welcome Reception – Exhibits and Posters |
| Thursday, 14 January, 2021 | |
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| 07:00 – 18:30 | Registration/Information |
| 07:00 – 08:30 | Breakfast |
| 08:30 – 12:00 | Plenary Session Pain and Sensory Mechanisms Chair: Mark Hallett (USA) |
| 08:30 – 08:40 | Opening Remarks and Introduction of Keynote Speaker |
| 08:40 – 09:30 | Keynote Presentation – The Neuromuscular Junction Stephen McMahon (UK) |
| 09:30 – 10:00 | Clinical Implications of Muscle Physiology Preeti Raghavan, MD (USA) |
| 10:00 – 10:30 | Basis of Movement Control and Why Botulinum Toxin Should Influence It Zdravko Lackovic (Croatia) |
| 10:30 – 11:00 | Exhibits & BREAK |
| 11:00 – 12:00 | Guidance, Localization, Optimal Placement of Botulinum Toxin: What Works Best? Hannes Gruber, MD (USA) Katharine Alter, MD (USA) Joseph Jankovic, MD (USA) |
| 12:00 – 13:30 | Lunch |
| 12:00 – 14:30 | Exhibits |
| 12:00 – 14:30 | Poster Session |
| PARALLEL TRACKS | Basic Science Track | Clinical Track 1A | Clinical Workshop 1A | Clinical Workshop 2A | Clinical Workshop 3A | Clinical Workshop 4A | Clinical Workshop 5A | ||
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| 14:30 – 16:00 | Emerging Toxins and Toxin Engineering Co-chairs: Eric Johnson (USA) Miia Lindström (Finland) |
Current and Emerging GI/GU Applications of BoNT Session Chair: Michael Chancellor (USA) |
Cadaver Laboratory – Prosection of the Head and Neck – A Mostly Aesthetic Perspective Session Chair: Steven G. Yoelin (USA) |
Newly-Diagnosed Cervical Dystonia Session Chair: Cynthia Comella (USA) |
Adult Spasticity Session Chair: Alberto Esquenazi (USA) |
Lower Cranial Dystonias and Drooling Session Chair: Andrew Blitzer (USA) |
Hands-on Ultrasound Guidance Workshop Session Chair: Katharine Alter (USA) Learn more |
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| 14:30 – 15:00 | What Defines a Botulinum Neurotoxin–Toxin Diversity Eric Johnson (USA) |
Clinical Applications in the Male GU Tract: Benign Prostatic Hyperplasia, Chronic Pelvic Pain Syndrome, Cancer Emmanuel Chartier-Kastler (France) Potential Clinical Applications for BoNT in the GI Tract Frank Zerbib (France) The Role of BoNT in “Classic” Bladder Disorders: Clinical Update Christopher Smith (USA) |
Prosectors: Timothy Greco (USA) Peter Palhazi (Hungary) Discussants: Steven G. Yoelin (USA) Wendy Lee (USA) |
What to Say to a Newly Diagnosed Patient and How to Manage Expectations Cynthia Comella (USA) How to Advise a Patient with CD: Exercise, Daily Living, Retraining Lena Zetterberg (Sweden) Strategy for Starting BoNT Treatment (written consent, initial dose and subsequent doses, interval, follow-up) Joseph Tsui (Canada) |
From Benchmark to the Latest Clinical Data: Evidence for the Use of BoNT in the Upper Extremity Jorg Wissel (Germany) Evidence for the Use of BoNT in the Lower Extremity Cindy Ivanhoe (USA) The Comprehensive Approach to The Management of Spasticity: Chemodenervation and Adjunctive Therapies Jean-Michel Gracies (France) The Anticoagulated Patient: Management Challenges Chris Boulias (Canada) |
Oromandibular and Laryngeal Dystonia Andrew Blitzer (USA) |
Hands-on Ultrasound Guidance – Upper Extremity Katharine Alter (USA) Florian Heinen (Germany) Barbara Karp (USA) Heakyung Kim (USA) Serdar Kocer (Switzerland) David Simpson (USA) |
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| 15:00 – 15:30 | Discovery of Novel Botulinum Therapeutics: A Binary Approach Bazbek Davletov (UK) |
Dystonic Swallowing, Speech and Breathing Difficulties: What the Injector Needs to Know Lucy Hicklin (UK) |
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| 15:30 – 16:00 | Chimeras of Anthrax Toxin and Botulinum Neurotoxin as Novel Analgesic Proteins Nicole Yang (USA) Botulinum Neurotoxin B Engineered for Increased Receptor Affinity Has Improved Clinical Potential Johannes Krupp (UK) |
Cervical Dystonia in Rotation: Different Injection Protocols for Different Clinical Phenotypes Video Case Studies Speaker: Joseph Jankovic (USA) |
Lip and Tongue Dystonia: “Drooling Along the Way” Raymond Rosales (Philippines) |
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| Early and Consistent Improvements in Urinary Symptoms and Quality of Life With OnabotulinumtoxinA in Overactive Bladder Patients With Urinary Incontinence in a Multicenter, Randomized, Placebo-Controlled, Phase 4 Trial Alfred Kohan (USA) |
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| 16:00 – 16:30 | BREAK | BREAK | BREAK | BREAK | BREAK | BREAK | BREAK | ||
| PARALLEL TRACKS | Basic Science Track | Clinical Track 1B | Clinical Workshop 1B | Clinical Workshop 2B | Clinical Workshop 3B | Clinical Workshop 4B | Clinical Workshop 5B | ||
| 16:30 – 18:30 | Mode of Action of BoNTs Co-chairs: Mauricio Montal (USA) Thomas Binz (Germany) |
Other Neurological Uses for BoNT Session Chair: Francisco Cardoso (Brazil) |
Cosmetic and Dermatologic Uses Moderator: Steven G. Yoelin (USA) |
Cervical Dystonia Injection Workshop I Moderator: Carlos Singer (USA) |
Adult Spasticity Injection Workshop Moderator: Anthony Ward (UK) |
Oromandibular Dystonia and Spasmodic Dysphonia Injection Workshop Moderator: Stewart Factor (USA) |
Hands-on Ultrasound Guidance Workshop Session Chair: Katharine Alter (USA) Learn more |
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| 16:30 – 17:00 | Structural Insights into BoNT Receptor Interaction or Into BoNT Complexes Richard Kammerer (Switzerland) |
Management of Sialorrhea Wolfgang Jost (Germany) |
Pooled Results From 2 Phase 3 Pivotal Studies of DaxibotulinumtoxinA for the Treatment of Glabellar Lines Steven G. Yoelin (USA) |
Demonstrations on Live Patients Master Injector: Torben Dalager (Denmark) |
Demonstrations on Live Patients Master Injector: Bo Biering-Sørensen (Denmark) |
Demonstrations on Live Patients Master Injector: Gohar Nikoghosyan-Bossen (Denmark) Master Injector: Heidi Bryde Biernat (Denmark) |
Hands-on Ultrasound Guidance – Lower Extremity Katharine Alter (USA) Florian Heinen (Germany) Barbara Karp (USA) Heakyung Kim (USA) Serdar Kocer (Switzerland) |
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| 17:00 – 17:30 | Mutations in Light Chain of Botulinum Neurotoxin A Enable Cleavage of Human Snap-23 Thomas Binz (Germany) The Structure of the Tetanus Toxin Reveals pH-Mediated Domain Dynamics Geoffrey Masuyer (Sweden) |
The Utility of BoNT in Parkinson’s–Beyond Sialorrhea Fernando Pagan (USA) |
Injection Workshop I – Demonstrations on Live Patients Master Injector: Jesper Thulesen (Denmark) |
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| 17:30 – 18:00 | Basic Biology of BoNTs Suzanne Kalb (USA) |
OnabotulinumtoxinA Treatment for Chronic Migraine Reduces Depression and Anxiety in Headache Day Frequency Responders and Nonresponders Mitchell F. Brin (USA) Botulinum Toxin for the Treatment of Hand Tremor Nicki Niemann (USA) |
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| 18:00 – 18:30 | Identification and Characterization of a Botulinum Neurotoxin–Like Toxin in a Commensal Strain of Enterococcus faecium Michael J. Mansfield (Canada) Novel Aspects of Intestinal Botulism Francois Douillard (Finland) |
OnabotulinumtoxinA Treatment Utilization Varies by Etiology of Spasticity, While Maintaining High Patient and Clinician Satisfaction: Results from the Aspire Study Gerard E. Francisco (USA) AbobotulinumtoxinA and Rehabilitation Versus Rehabilitation Alone in Poststroke Spasticity: An Italian Cost-Utility Analysis Alessio Baricich (Italy) |
| Friday, 15 January, 2021 | |
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| 07:00 – 18:30 | Registration/ Information |
| 07:00 – 08:30 | Exhibits & Breakfast |
| 08:30 – 12:00 | Plenary Session Duration of Action Co-chairs: Matteo Caleo (Italy) David Simpson (USA) |
| 08:30 – 09:00 | Clinical Duration of Action of Different Toxin Types Roberto Eleopra (Italy) |
| 09:00 – 09:30 | Came to Stay: Receptor Interactions of Botulinum Neurotoxins Andreas Rummel (Germany) |
| 09:30 – 10:00 | Are Booster Injections Safe? Dirk Dressler (Germany) |
| 10:00 – 10:30 | Break |
| 10:30 – 11:00 | Cell Entry, Activation and Intracellular Persistence of BoNT Light Chains Marco Pirazzini (Italy) |
| 11:00 – 11:30 | Super-Resolving Botulinum Neurotoxin Type-A Molecules: From Surface Landing to Internalization in Synaptic Vesicles Frederic Meunier (Australia) |
| 11:30 – 12:00 | Duration of Action in Dermatology/Aesthetics Nowell Solish (Canada) |
| 12:00 – 13:30 | Lunch |
| 12:00 – 14:30 | Exhibits |
| 12:00 – 14:30 | Poster Session |
| PARALLEL TRACKS | Basic Science Track | Clinical Workshop 1A | Clinical Workshop 2A | Clinical Workshop 3A | Clinical Workshop 5A | Clinical Workshop 6A | ||
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| 14:30 – 16:00 | Neuronal Plasticity and Trafficking of BoNTs Co-chairs: Ornella Rossetto (Italy) Yukako Fujinaga (Japan) |
Pediatric Spasticity and Movement Disorders Session Chair: Florian Heinen (Germany) |
Cosmetic and Dermatologic Applications of Botulinum Toxin Session Chair: Steven G. Yoelin (USA) |
Cervical Dystonia II Session Chair: Ryuji Kaji (Japan) |
Hemifacial Spasm and Blepharospasm Session Chair: Marie Vidailhet (France) |
Hands-on Ultrasound Guidance Workshop Session Chair: Katharine Alter (USA) Learn more |
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| 14:30 – 15:00 | Neuronal Selectivity of BoNTs Michel Popoff (France) |
Review of Common Gait Patterns in Children With Cerebral Palsy Mark Gormley (USA) |
“Classic” Cosmetic Use of Botulinum Toxins: From Glabella to Platysma: Injection Techniques to Maximize Outcomes Timothy Greco (USA) |
Anterocollis Posture and Deep Cervical Muscle Injections With BoNT Laxman Bahroo (USA) |
The Patient’s Perspective: Personal Experience, Psychological Profile and Social Media Marie Vidailhet (France) |
Hands-on Ultrasound Guidance – Upper Extremity Katharine Alter (USA) Barbara Karp (USA) Heakyung Kim (USA) Serdar Kocer (Switzerland) Michael Munin (USA) |
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| 15:00 – 15:30 | Neuronal Plasticity and BoNTs as Pain Therapeutics Maria Maiaru (UK) |
Neurotoxin Therapy vs Physical Treatments: What Is the Optimal Approach for the Pediatric Patient? Henk Stam (Netherlands) |
Challenging Botulinum Toxin Cases, Bridging Cosmetic and Therapeutic Nowell Solish (Canada) Escalating Doses of IncobotulinumtoxinA for Extended Treatment of Glabellar Frown Lines: Safety and Efficacy Results From a Randomized, Double-Blind Study Corey Maas (USA) |
Cervical Dystonia Revisited Alberto Albanese (Italy) |
Blepharospasm and Hemifacial Spasm: Different Injection Protocols for Different Clinical Phenotypes Video Case Studies Mark Hallett (USA) |
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| 15:30 – 16:00 | Exploring the Effect of Various BoNT Serotypes in a Model of Autonomic Nervous System Hyperactivity From Rodents and Humans: Paving the Way to Better Targeting Therapeutics in Autonomic Disorders? Jacquie Maignel (France) Centrally Transported Botulinum Toxin Type A Relieves Local Spastic Paralysis Ivica Matak (Croatia) |
Where do ‘Toxins’ Fit in the Care Pathway of Pediatric Dystonia and Cerebral Palsy? Darcy Fehlings (Canada) |
Outcomes of Week-24 Completers and Subjects Who Had Follow-Up Beyond Week 24 After a Single Treatment of DaxibotulinumtoxinA for Injection (Rt002): Results of a Phase 2, Open-Label (Level II), Dose-Escalating Study in Isolated Cervical Dystonia Atul Patel (USA) Management Algorithm for BoNT Injections with Electromyography and Ultrasound Guidance in Cervical Dystonia Anna Castagna (Italy) |
Facial Tics Joseph Jankovic (USA) |
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| 16:00 – 16:30 | BREAK | BREAK | BREAK | BREAK | BREAK | BREAK | ||
| PARALLEL TRACKS | Basic Science Track | Clinical Workshop 1B | Clinical Workshop 2B | Clinical Workshop 3B | Clinical Workshop 4 | Clinical Workshop 5B | Clinical Workshop 6B | |
| 16:30 – 18:30 | Protection and Detection Co-chairs: Sabine Pellett (USA) Sheng Chen (China) |
Pediatric Spasticity Moderator: Cindy Ivanhoe (USA) |
Focal Limb Dystonia Moderator: David Simpson (USA) |
Cervical Dystonia Injection Workshop II Moderator: Alberto Albanese (Italy) |
Primary Headache Session Chair: Cristina Tassorelli (Italy) |
Hemifacial, Blepharospasm and Sialorrhea Injection Workshop Moderator: Raymond Rosales (Philippines) |
Hands-on Ultrasound Guidance Workshop Session Chair: Katharine Alter (USA) Learn more |
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| 16:30 – 17:00 | The Development of Catalytically Inactive Botulinum Neurotoxin Holoproteins Robert Webb (USA) |
Efficacy and Safety of IncobotulinumtoxinA for Lower-Limb Spasticity in Children and Adolescents with Cerebral Palsy Florian Heinen (Germany) |
Focal Limb Dystonia and Tremor: Clinical Update Mandar Jog (Canada) |
Demonstrations on Live Patients Master Injector: Theódora Hannesdóttir Cleemann (Denmark) |
Pathophysiology of Migraine: Migraine Pain vs Other Types of Chronic Pain–Similarities and Differences Anthony Dickenson (UK) |
Demonstrations on Live Patients Master Injector: Heidi Bryde Biernat (Denmark) |
Hands-on Ultrasound Guidance – Head and Neck Katharine Alter (USA) Barbara Karp (USA) Heakyung Kim (USA) Serdar Kocer (Switzerland) Michael Munin (USA) |
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| 17:00 – 17:30 | RNA-Based Therapeutics Charles Shoemaker (USA) |
Video Case Studies Presented by: Florian Heinen (Germany) Cindy Ivanhoe (USA) Sebastian Schroeder (Germany) |
Focal Limb Dystonia Injection Workshop Moderator: Mark Hallett (USA) |
Predictors of Response to BoNT in Chronic Migraine Patricia Pozo-Rosich (Spain) |
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| 17:30 – 18:00 | Small Molecule Inhibitors to BoNTs Kim Janda (USA) |
Demonstrations on Live Patients Master Injector: Torben Dalager (Denmark) |
Video Case Studies | |||||
| 18:00 – 18:30 | Development of an In Vitro Human Neuromuscular Junction Camille Nicoleau (France) Catwalk™ as a Functional Analysis Tool of Rodents Injected With Botulinum Neurotoxin Sabine Pellett (USA) |
| Saturday, 16 January, 2021 | |
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| 07:00 – 12:00 | Registration/ Information |
| 07:00 – 08:30 | Exhibits & Breakfast |
| 08:00 – 09:00 | INA Members Business Meeting |
| 09:00 – 11:15 | Plenary Session – New Toxins Chair: Giampietro Schiavo (UK) |
| 09:00 – 09:30 | What Properties Do Clinicians and Patients Want? Jörg Wissel (Germany) |
| 09:30 – 10:00 | Family of BoNTs and New Toxins Pål Stenmark (Sweden) |
| 10:00 – 10:30 | New Versions of BoNT Including Transdermal Preparations and Type E: New Clinical Indications: Ongoing Clinical Trials Cynthia Comella (USA) |
| 10:30 – 11:00 | Toxin Engineering Min Dong (USA) |
| 11:00 – 11:15 | Conference Closing Remarks Cynthia Comella (USA) |